글로벌 연구동향
방사선종양학
- 2018년 12월호
[Int J Clin Oncol.] Analysis of unexplained carcinoembryonic antigen elevation after curative treatment of locally advanced rectal cancer.국립암센터 / 이성욱, 김대용*
- 출처
- Int J Clin Oncol.
- 등재일
- 2018 Oct
- 저널이슈번호
- 23(5):924-929. doi: 10.1007/s10147-018-1293-4. Epub 2018 May 17.
- 내용
Abstract
BACKGROUND:
To analyze the causes and patterns of unexplained carcinoembryonic antigen (CEA) elevation after curative treatment in locally advanced rectal cancer patients.METHODS:
Among the 1309 locally advanced rectal cancer patients treated with curative resection and radiotherapy between January 2001 and June 2011, 325 patients who postoperatively developed abnormal CEA elevation were reviewed. The unexplained CEA elevation was defined as a CEA level higher than 5 ng/mL with no evidence of cancer recurrence at the time of elevation.RESULTS:
Of the 325 patients, 143 (44%) had unexplained CEA elevations. The causes were categorized as delayed recurrence (n = 29, 20%), non-colorectal malignancy (n = 10, 7%), and non-malignancy-related conditions (n = 104, 73%). Shorter intervals between treatment and the first CEA elevation, and a higher peak CEA level, were observed in the delayed recurrence group compared with the non-colorectal malignancy or non-malignancy-related group (intervals of 6.8 vs. 44.9 vs. 23.2 months, respectively, p = 0.002; and peak CEA levels of 9.9 vs. 7.1 vs. 6.2 ng/mL, respectively, p = 0.034). In patients who showed delayed recurrence, the interval between the first CEA elevation and diagnosis of recurrence was a median of 13.0 months (range 3.8-60.6 months). Smoking was the most common cause for non-malignancy-related conditions. The patterns of unexplained CEA elevations were defined as sporadic (n = 78, 55%), stationary (n = 37, 26%), and increasing (n = 28, 20%). The patterns were significantly different depending on the cause (p < 0.001).CONCLUSIONS:
Analysis of the patterns of unexplained CEA elevations is a reasonable approach to predict the cause of the cancer.
Author informationLee SU1, Jwa E1, Kim DY2, Kim TH1, Baek JY1, Cha Y1, Chang HJ1, Oh JH1.
1
Center for Colorectal Cancer, National Cancer Center, Goyang, Republic of Korea.
2
Center for Colorectal Cancer, National Cancer Center, Goyang, Republic of Korea. radiopia@ncc.re.kr.
- 키워드
- Carcinoembryonic antigen; Rectal cancer; Smoking; Surveillance
- 덧글달기
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편집위원
임상적으로 종종 접하게 되는, 설명되지 않는 CEA 상승의 원인을 분석한 논문
덧글달기닫기2018-12-14 16:46:47
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