서울의대, 이화의대 / 김병혁, 권진이, 지의규*, 김규보*
Abstract
BACKGROUND:
The impact of adjuvant radiotherapy (ART) on survival from gallbladder carcinoma (GBC) remains underexplored, with conflicting results reported. A systematic review and meta-analysis was performed to clarify the impact of ART in GBC.
METHODS:
A systematic literature search of several databases was performed following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, from inception to August 2016. Studies that reported survival outcomes for patients with or without ART after curative surgery were included.
RESULTS:
All the inclusion criteria was met by 14 retrospective studies including 9364 analyzable patients, but most of the studies had a moderate risk of bias. Generally, the ART group had more patients with unfavorable characteristics than the group that had surgery alone. Nevertheless, the pooled results showed that ART significantly reduced the risk of death (hazard ratio [HR], 0.54; 95% confidence interval [CI] 0.44-0.67; p < 0.001) and recurrence (HR 0.61; 95% CI 0.38-0.98; p = 0.04) of GBC compared with surgery alone. Exploratory analyses demonstrated a survival benefit from ART for a subgroup of patients with lymph node-positive diseases (HR 0.61; p < 0.001) and R1 resections (HR 0.55; p < 0.001), but not for patients with lymph node-negative disease (HR 1.06; p = 0.78). No evidence of publication bias was found (p = 0.663).
CONCLUSIONS:
This study is the first meta-analysis to evaluate the role of ART and to provide supporting evidence that ART may offer survival benefits, especially for high-risk patients. However, further confirmation with a randomized prospective study is needed to clarify the subgroup of GBC patients who would benefit most from ART.
Author information
Kim BH1, Kwon J2, Chie EK3,4, Kim K5, Kim YH6, Seo DW7, Narang AK8, Herman JM8.
1
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
2
Department of Radiation Oncology, Chungnam National University College of Medicine, Daejeon, Korea.
3
Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea. ekchie93@snu.ac.kr.
4
Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Korea. ekchie93@snu.ac.kr.
5
Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Korea. kyubokim.ro@gmail.com.
6
Department of General Surgery, Dong-A University College of Medicine, Busan, Korea.
7
Department of Gastroenterology, Asan Medical Center, University of Ulsan Medical College, Seoul, Korea.
8
Department of Radiation Oncology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
편집위원
A systematic review and meta-analysis: 메타분석의 이유 중에 하나가 질환의 희귀성, 연구 결과의 다양성때문인데 Gallbladder cancer가 그러한 성격을 가지고 있다. 이 연구 또한 방사선치료의 역할 규명을 위한 기초가 될 것으로 판단되어 흥미로웠습니다.
2017-12-12 15:32:30