방사선의학 웹진

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Abstract

PURPOSE:

This study was conducted to evaluate the long-term outcome in patients undergoing pancreaticoduodenectomy (PD) followed by adjuvant chemoradiotherapy for distal cholangiocarcinoma (DCC) in a high-volume center and to identify the prognostic impact of clinicopathologic factors.

MATERIALS AND METHODS:

A total of 132 consecutive patients who met the inclusion criteria were retrieved from the institutional database from January 1995 to September 2009. All patients received adjuvant treatments at a median of 45 days after the surgery. Median follow-up duration was 57 months (range, 6 to 225 months) for all patients and 105 months for survivors (range, 13 to 225 months).

RESULTS:

The 5-year locoregional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS), disease-free survival (DFS), and overall survival (OS) rates were 70.7%, 55.7%, 49.4%, and 48.1%, respectively. Univariate analysis revealed poorly differentiated (P/D) tumors and lymph node (LN) metastasis were significantly associated with DMFS and OS. Additionally, preoperative carbohydrate antigen 19-9 level was significantly correlated with DFS, LRRFS, and DMFS. Upon multivariate analysis for OS, P/D tumors (p=0.015) and LN metastasis (p=0.003) were significant prognosticators that predicted inferior OS. Grade 3 or higher late gastrointestinal toxicity occurred in only one patient (0.8%).

CONCLUSION:

Adjuvant chemoradiotherapy after PD for DCC is an effective and tolerable strategy without significant side effects. During long-term follow-up, we found that prognosis of DCC was mainly influenced by histologic differentiation and LN metastasis. For patients with these risk factors, further research should focus on improving adjuvant strategies as well as other treatment approaches.

Author information

Kim BH1,2, Kim K3, Chie EK1, Kwon J1,4, Jang JY5, Kim SW5, Oh DY6, Bang YJ6.

1 Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.

2 Division of Biological Warfare Preparedness and Response, Armed Forces Medical Research Institute, Daejeon, Korea.

3 Department of Radiation Oncology, Ewha Womans University School of Medicine, Seoul, Korea.

4 Department of Radiation Oncology, Chungnam National University School of Medicine, Daejeon, Korea.

5 Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

6 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.