글로벌 연구동향
핵의학
- 2022년 04월호
[Synapse.] SLC6A3 gene polymorphisms are associated with striatal dopamine transporter changes after glucose loading부산대병원 / 박경준*, 서성호
- 출처
- Synapse.
- 등재일
- 2022 Feb
- 저널이슈번호
- 76(1-2):e22223. doi: 10.1002/syn.22223. Epub 2022 Feb 14.
- 내용
Abstract
We investigated the association between SLC6A3 gene polymorphisms and changes in dopamine transporter (DAT) availability after glucose loading in humans. An intravenous injection of 18 F-FP-CIT was administered after infusion of glucose or placebo, and the emission data were acquired over 90 min in 38 healthy male participants. DAT availability expressed in terms of binding potential (BPND ) was recorded. The 40-bp variable number of tandem repeats (VNTR) in the 3' untranslated region and two single nucleotide polymorphisms (SNPs), rs2652511 and rs2937639, in the SLC6A3 gene were genotyped. Among the 38 participants, those with a VNTR other than 10R/10R (n = 7) were excluded. The alleles of the two SNPs (rs2652511 and rs2937639) appeared to be inherited together in two fixed combinations (C-G or T-A) in 29 of 31 individuals. The BPND in the ventral striatum (VST), caudate nucleus, and putamen was not significantly different after glucose or placebo loading according to genotype. However, BPND s from the caudate nucleus and putamen of all participants with rs2652511 CT/rs2937639 AG (n = 6) were higher after glucose loading. In conclusion, the SLC6A3 gene polymorphism is associated with the changes in DAT availability after glucose loading. DAT availability after glucose or placebo loading in the VST, caudate nucleus, and putamen did not differ according to the SLC6A3 genotype.Affiliations
Kyoungjune Pak 1 , Seongho Seo 2 , Keunyoung Kim 1 , Myung Jun Lee 3 , In Joo Kim 1
1 Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
2 Department of Electronic Engineering, Pai Chai University, Daejeon, Republic of Korea.
3 Department of Neurology, Pusan National University Hospital, Busan, Republic of Korea.
- 키워드
- Dopamine plasma membrane transport proteins; Genetic polymorphism; Glucose.
- 연구소개
- F18-FP-CIT PET을 이용하여, ‘glucose loading에 의한 dopamine transporter (DAT)의 변화’에 영향을 미치는 single nucleotide polymorphism을 확인한 연구임. VNTR 10R/10R에 해당하는 대상자 중 rs2652511과 rs2937639에 따라 두 개의 그룹으로 구분 후, DAT의 변화를 비교하였고, SLC6A3 gene polymorphism에 따라서 차이가 있음을 확인함.
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