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  • 2018년 09월호
    [Ann Nucl Med.] Effects of rs591323 on serotonin transporter availability in healthy male subjects.

    부산대 / 박경준*, 남현열*, 김성장*, 김인주*

  • 출처
    Ann Nucl Med.
  • 등재일
    2018 Aug
  • 저널이슈번호
    32(7):431-436. doi: 10.1007/s12149-018-1262-z. Epub 2018 May 17.
  • 내용

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    Abstract
    OBJECTIVES:
    We aimed to investigate the association between genetic factors of SNPs dopamine transporter (DAT) and serotonin transporter (SERT) availabilities in healthy controls.

    METHODS:
    The study population consisted of healthy controls with screening 123I-FP-CIT single-photon emission computed tomography. Specific binding of 123I-FP-CIT regarding DAT and SERT was calculated using a region of interest analysis. VOI template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, striatum, midbrain, and pons.

    RESULTS:
    One hundred sixty healthy controls (male 106, female 54, 61.0 ± 11.5 years) were included in this study. Sex difference did not exist in DAT availabilities of caudate nucleus (p = 0.5344), putamen (p = 0.5006), and striatum (p = 0.5056). However, male subjects had higher SERT availabilities of both midbrain (p = 0.0436), and pons (p = 0.0061). Therefore, we analyzed the effect of SNP on DAT availabilities of subjects in all, and that on SERT availabilities of males and females separately. None of 19 SNPs included in this study showed the effect on DAT availabilities. However, rs591323 in Fibroblast Growth Factor 20 on chromosome 8 had a significant impact on SERT availability of both midbrain (p = 0.0056) and pons (p = 0.0007).

     


    Author information

    Pak K1, Nam HY2, Shin S3, Kim K3, Lee MJ4, Kim EJ4, Lee JM5, Kim SJ6, Kim IJ7.
    1
    Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, Republic of Korea. ilikechopin@me.com.
    2
    Department of Nuclear Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea. octobre23@hanmail.net.
    3
    Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, Republic of Korea.
    4
    Department of Neurology and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
    5
    Department of Neurosurgery and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
    6
    Department of Nuclear Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. growthkim@daum.net.
    7
    Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, Republic of Korea. injkim@pusan.ac.kr.

  • 키워드
    SPECT; Serotonin transporter; Single nucleotide polymorphism
  • 편집위원

    CIT SPECT 영상을 기반으로 하여 serotonin transporter availability와 single nucleotide polymorphism과의 관계를 조사한 연구임.
    내용 자체도 흥미로우나 공개된 database (Parkinson’s Progression Markers Initiative(PPMI))를바탕으로진행한연구로이러한시도와 PPMI에 대해 독자들에게 널리 알릴 만한 가지가 있다고 생각함.

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