글로벌 연구동향
핵의학
- 2017년 10월호
[Front Immunol.] Molecular Imaging: A Useful Tool for the Development of Natural Killer Cell-Based Immunotherapies.경북의대 / Prakash Gangadaran, 안병철*
- 출처
- Front Immunol.
- 등재일
- 2017 Sep 12
- 저널이슈번호
- 8:1090. doi: 10.3389/fimmu.2017.01090. eCollection 2017.
- 내용
Abstract
Molecular imaging is a relatively new discipline that allows visualization, characterization, and measurement of the biological processes in living subjects, including humans, at a cellular and molecular level. The interaction between cancer cells and natural killer (NK) cells is complex and incompletely understood. Despite our limited knowledge, progress in the search for immune cell therapies against cancer could be significantly improved by dynamic and non-invasive visualization and tracking of immune cells and by visualization of the response of cancer cells to therapies in preclinical and clinical studies. Molecular imaging is an essential tool for these studies, and a multimodal molecular imaging approach can be applied to monitor immune cells in vivo, for instance, to visualize therapeutic effects. In this review, we discuss the usefulness of NK cells in cancer therapies and the preclinical and clinical usefulness of molecular imaging in NK cell-based therapies. Furthermore, we discuss different molecular imaging modalities for use with NK cell-based therapies, and their preclinical and clinical applications in animal and human subjects. Molecular imaging has contributed to the development of NK cell-based therapies against cancers in animal models and to the refinement of current cell-based cancer immunotherapies. Developing sensitive and reproducible non-invasive molecular imaging technologies for in vivo NK cell monitoring and for real-time assessment of therapeutic effects will accelerate the development of NK cell therapies.
Author information
Gangadaran P1, Ahn BC1.
1 Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, Daegu, South Korea.
- 키워드
- bioluminescence; cell trafficking; molecular imaging; natural killer cell; positron-emission tomography; single photon-emission computed tomography; therapy
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편집위원
세포지료술의 개발에 분자영상 기여 개괄적으로 정리한 리뷰논문으로 핵의학 임상 및 기초 연구자들에게 큰 관심을 끌 논문으로 생각된다.
덧글달기닫기2017-10-17 17:24:49
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