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Abstract

The accurate detection of disease-related biomarkers is crucial for the early diagnosis and management of disease in personalized medicine. Here, we present a molecular imaging of human epidermal growth factor receptor (EGFR)-expressing malignant tumors using an EGFR-specific repebody composed of leucine-rich repeat (LRR) modules. The repebody was labeled with either a fluorescent dye or radioisotope, and used for imaging of EGFR-expressing malignant tumors using an optical method and positron emission tomography. Our approach enabled visualization of the status of EGFR expression, allowing quantitative evaluation in whole tumors, which correlated well with the EGFR expression levels in mouse or patients-derived colon cancers. The present approach can be effectively used for the accurate detection of EGFR-expressing cancers, assisting in the development of a tool for detecting other disease biomarkers.

Author information

Yun M1, Kim DY1, Lee JJ2,3, Kim HS1, Kim HS4, Pyo A1, Ryu Y2, Kim TY2, Zheng JH1,5, Yoo SW1, Hyun H6, Oh G7, Jeong J8, Moon M9, Min JH10, Kwon SY1, Kim JY11, Chung E7, Hong Y8, Lee W12, Kim HS2, Min JJ1,5,8.

1 Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital, Jeonnam, Republic of Korea.

2 Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

3 Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Republic of Korea.

4 Department of Forensic Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.

5 Department of Molecular Medicine (BK21plus), Chonnam National University Graduate School, Gwangju, Republic of Korea.

6 Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea.

7 School of Mechanical Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea.

8 Department of Microbiology, Chonnam National University Medical School, Gwangju, Republic of Korea.

9 Department of Radiology, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea.

10 Department of Biology, Kyung Hee University College of Science, Seoul, Republic of Korea.

11 Division of RI-Convergence Research, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.

12 Department of Gastroenterology, Chonnam National University Hwasun Hospital, Jeonnam, Republic of Korea.