글로벌 연구동향
방사선종양학
- 2017년 01월호
[Oncotarget.] Metformin enhances the radiosensitivity of human liver cancer cells to γ-rays and carbon ion beams.KIRAMS, QST(NIRS) / 김은호, 김미숙* , Sei Sai*
- 출처
- Oncotarget.
- 등재일
- 2016 Oct 27.
- 저널이슈번호
- doi: 10.18632/oncotarget.12966. [Epub ahead of print]
- 내용
Abstract
The purpose of this study was to investigate the effect of metformin on the responses of hepatocellular carcinoma (HCC) cells to γ-rays (low-linear energy transfer (LET) radiation) and carbon-ion beams (high-LET radiation). HCC cells were pretreated with metformin and exposed to a single dose of γ-rays or carbon ion beams. Metformin treatment increased radiation-induced clonogenic cell death, DNA damage, and apoptosis. Carbon ion beams combined with metformin were more effective than carbon ion beams or γ-rays alone at inducing subG1 and decreasing G2/M arrest, reducing the expression of vimentin, enhancing phospho-AMPK expression, and suppressing phospho-mTOR and phospho-Akt. Thus, metformin effectively enhanced the therapeutic effect of radiation with a wide range of LET, in particular carbon ion beams and it may be useful for increasing the clinical efficacy of carbon ion beams.
Author information
Kim EH1, Kim MS2, Furusawa Y3, Uzawa A3, Han S1, Jung WG1, Sai S3.
1Division of Heavy Ion Clinical Research, Korea Institute of Radiological and Medical Sciences, Gongneung-dong, Nowon-Gu, Seoul, South Korea.
2Department of Radiation Oncology, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.
3Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.
- 키워드
- DNA damage; carbon ion beam; hepatocellular carcinoma cell; metformin; radiosensitivity
- 덧글달기
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