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Abstract

Siva and colleagues have demonstrated that localized thoracic radiation resulted in DNA damage at out-of-field sites. Although these interesting findings require validation, we discuss the important clinical implications of these data, especially in the era of immune therapies.​ 

- See related article by Siva et al., p. 4817.​

1. 1. 
   1. Siva S, 
   2. Lobachevsky P, 
   3. MacManus MP, 
   4. Kron T, 
   5. Möller A,
   6. Lobb RJ, 
   7. et al.

    Radiotherapy for non-small cell lung cancer induces DNA damage response in both irradiated and out-of-field normal tissues. Clin Cancer Res 2016;22:4817–26.

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Author information​

Verma V1, Lin SH2.

1Department of Radiation Oncology, University of Nebraska Medical Center, Omaha, Nebraska.

2Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas. SHLin@mdanderson.org.