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분자영상 및 방사화학
- 2022년 11월호
[Nanomaterials (Basel) .] Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell ViabilityKAERI / 장해민, 박준규*, 조원진*
- 출처
- Nanomaterials (Basel) .
- 등재일
- 2022 Aug 14
- 저널이슈번호
- 12(16):2791. doi: 10.3390/nano12162791.
- 내용
Abstract
We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope 64Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T2 MRI nanoprobe due to their good r2/r1 ratio. Furthermore, we demonstrate that the 64Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.Affiliations
Hye Min Jang 1 2, Myung Hwan Jung 1, Jae Sang Lee 1, Jun Sig Lee 3, In-Cheol Lim 3, Hyunsik Im 2, Sang Wook Kim 4, Sung-A Kang 5, Won-Je Cho 1, Jun Kue Park 1
1Korea Multi-Purpose Accelerator Complex, Korea Atomic Energy Research Institute, 181 Mirae-ro, Gyeongju 38180, Korea.
2Division of Physics and Semiconductor Science, Dongguk University, Seoul 04620, Korea.
3Korea Atomic Energy Research Institute, Daedeok-daero 989, Daejeon 34057, Korea.
4Department of Advanced Materials Chemistry, Dongguk University, Gyeongju 38066, Korea.
5Advanced Bio Convergence, Pohang Technopark, Pohang 37668, Korea.
- 키워드
- PET-MRI; contrast agents; magnetic relaxivity; multimodal imaging; nanoparticles; silica core-shell; superparamagnetic nanoparticles.
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