글로벌 연구동향
분자영상 및 방사화학
- 2022년 10월호
[J Mater Chem B.] Dilute lattice doping of 64 Cu into 2D-nanoplates: its impact on radio-labeling efficiency and stability for target selective PET imaging 2D 나노플레이트에 64Cu의 격자 도핑 희석: 표적 선택적 PET 이미징을 위한 방사성 표지 효율성 및 안정성에 미치는 영향단국대 / 엄새란, 최진호*
- 출처
- J Mater Chem B.
- 등재일
- 2022 Aug 5. doi: 10.1039/d2tb01165d. Online ahe
- 저널이슈번호
- 내용
Abstract
A quintinite nanoplate (64Cu-QT-NP) isomorphically substituted with 64Cu, as the positron emission tomography (PET) imaging material, was prepared via two-step processes. A 64Cu labeling efficiency of 99% was realized, for the first time, by immobilizing the 64Cu radioisotope directly in the octahedral site of the 2-dimensional (2D) quintinite lattice. Furthermore, the 64Cu labeling stability of 64Cu-QT-NPs was also achieved to be more than ∼99% in various solutions such as saline, phosphate-buffered saline (PBS), and other biological media (mouse and human serums). In an in vivo xenograft mouse model, the passive targeting behavior of 64Cu-QT-NPs into tumor tissue based on the enhanced permeability and retention (EPR) effect was also demonstrated by parenteral administration, and successfully visualized using a PET scanner. For enhancing the tumor tissue selectivity, bovine serum albumin (BSA) was coated on 64Cu-QT-NPs to form 64Cu-QT-NPs/BSA, resulting in better colloidal stability and longer blood circulation time, which was eventually evidenced by the 2-fold higher tumor uptake rate when intravenousely injected in an animal model. It is, therefore, concluded that the present 64Cu-QT-NPs/BSA with tumor tissue selectivity could be an advanced nano-device for radio-imaging and diagnosis as well.Affiliations
Sairan Eom 1 2 , Min Hwan Kim 2 , Ranji Yoo 2 , Goeun Choi 3 4 5 , Joo Hyun Kang 2 , Yong Jin Lee 2 , Jin-Ho Choy 3 6 7
1 Center for Intelligent Nano-Bio Materials (CINBM), Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
2 Division of Applied-RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea.
3 Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea. jhchoy@dankook.ac.kr.
4 College of Science and Technology, Dankook University, Cheonan 31116, Republic of Korea.
5 Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea.
6 Department of Pre-medical Course, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea.
7 International Research Frontier Initiative (IRFI), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan.
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