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Abstract
We investigated whether the performance of serum thyroglobulin (Tg) for response prediction could be improved based on the iodine uptake pattern on the post-therapeutic I-131 whole body scan (RxWBS) and the degree of thyroid tissue damage with radioactive iodine (RAI) therapy. A total of 319 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and RAI therapy were included. Based on the presence/absence of focal uptake at the anterior midline of the neck above the thyroidectomy bed on RxWBS, patients were classified into positive and negative uptake groups. Serum Tg was measured immediately before (D0Tg) and 7 days after RAI therapy (D7Tg). Patients were further categorized into favorable and unfavorable Tg groups based on the prediction of excellent response (ER) using scan-corrected Tg developed through the stepwise combination of D0Tg with ratio Tg (D7Tg/D0Tg). We investigated whether the predictive performance for ER improved with the application of scan-corrected Tg compared to the single Tg cutoff. The combined approach using scan-corrected Tg showed better predictive performance for ER than the single cutoff of D0Tg alone (p < 0.001). Therefore, scan-corrected Tg can be a promising biomarker to predict the therapeutic responses after RAI therapy.

Author information

Yoo SW1, Chowdhury MSA1,2, Jeon S1, Kang SR1, Cho SG3, Kim J3, Lee C1,4, Ryu YJ5, Song HC3,4, Bom HS1,4, Min JJ1,4, Kwon SY1,4.
1
Department of Nuclear Medicine, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, Korea.
2
Institute of Nuclear Medicine and Allied Sciences, Bangladesh Atomic Energy Commission, Bogra 5800, Bangladesh.
3
Department of Nuclear Medicine, Chonnam National University Hospital, Gwangju 61469, Korea.
4
Department of Nuclear Medicine, Chonnam National University Medical School, Jeollanam-do 58128, Korea.
5
Department of Surgery, Chonnam National University Hwasun Hospital, Jeollanam-do 58128, Korea.