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Abstract
AIMS:
The dopamine transporter (DAT) actively translocates dopamine that is released from the presynaptic neurons across the membranes of nerve terminals into the extracellular space. We hypothesized that glucose loading-induced changes in striatal DAT levels could be associated with food intake in humans.

MATERIALS AND METHODS:
An intravenous bolus injection of 18 F-FP-CIT was administered after infusion of glucose or placebo (normal saline), and emission data were acquired over 90 minutes in 33 healthy males. For a volume-of-interest-based analysis, an atlas involving sub-striatal regions of ventral striatum (VST), caudate nucleus and putamen was applied. DAT availability and binding potential (BPND ) were measured using a simplified reference tissue method with cerebellum as the reference.

RESULTS:
The glucose-loaded BPND from the VST negatively correlated with body mass index (BMI), whereas the placebo-loaded BPND from the VST did not. After loading with glucose, there were substantial increases in BPND s: 18.3%, 71.7% and 34.0% on average in the VST, caudate nucleus and putamen, respectively.

CONCLUSION:
Striatal DAT changes after glucose loading, and BMI is associated with glucose-loaded DAT availability, not with placebo-loaded DAT availability. DAT might have a role in the reward system of eating behavior.

Author information

Pak K1, Seo S2,3, Kim K1, Lee MJ4, Shin MJ5, Suh S6, Im HJ7, Park JJ8, Kim SJ9, Kim IJ1.
1
Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
2
Department of Neuroscience, College of Medicine, Gachon University, Incheon, Republic of Korea.
3
Neuroscience Research Institute, Gachon University, Incheon, Republic of Korea.
4
Department of Neurology, Pusan National University Hospital, Busan, Republic of Korea.
5
Department of Rehabilitation Medicine, Pusan National University Hospital, Busan, Republic of Korea.
6
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Republic of Korea.
7
Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.
8
Division of Sport Science, Pusan National University, Busan, Republic of Korea.
9
Department of Nuclear Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.