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Abstract
Concurrent chemoradiotherapy (CRT) is the standard treatment for locally advanced cervical cancer (LACC), but its responsiveness varies among patients. A reliable tool for predicting CRT responses is necessary for personalized cancer treatment. In this study, we constructed prediction models using handcrafted radiomics (HCR) and deep learning radiomics (DLR) based on pretreatment MRI data to predict CRT response in LACC. Furthermore, we investigated the potential improvement in prediction performance by incorporating clinical factors. A total of 252 LACC patients undergoing curative chemoradiotherapy are included. The patients are randomly divided into two independent groups for the training (167 patients) and test datasets (85 patients). Contrast-enhanced T1- and T2-weighted MR scans are obtained. For HCR analysis, 1890 imaging features are extracted and a support vector machine classifier with a five-fold cross-validation is trained on training dataset to predict CRT response and subsequently validated on test dataset. For DLR analysis, a 3-dimensional convolutional neural network was trained on training dataset and validated on test dataset. In conclusion, both HCR and DLR models could predict CRT responses in patients with LACC. The integration of clinical factors into radiomics prediction models tended to improve performance in HCR analysis. Our findings may contribute to the development of personalized treatment strategies for LACC patients.

Affiliations

Sungmoon Jeong # 1 2, Hosang Yu # 2, Shin-Hyung Park 3 4 5, Dongwon Woo 2, Seoung-Jun Lee 6, Gun Oh Chong 7 8, Hyung Soo Han 8 9, Jae-Chul Kim 10 6
1Department of Medical Informatics, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
2Research Center for Artificial Intelligence in Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea.
3Department of Radiation Oncology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. shinhyungpark@knu.ac.kr.
4Department of Radiation Oncology, Kyungpook National University Hospital, Daegu, Republic of Korea. shinhyungpark@knu.ac.kr.
5Cardiovascular Research Institute, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. shinhyungpark@knu.ac.kr.
6Department of Radiation Oncology, Kyungpook National University Hospital, Daegu, Republic of Korea.
7Department of Gynecology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
8Clinical Omics Research Center, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
9Department of Physiology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
10Department of Radiation Oncology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
#Contributed equally.