방사선의학 웹진

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Abstract
Here, we report an efficient and highly active copper complex ([(TMPhen)2Cu(I)][O2CCF2Cl]) for the trifluoromethylation of aryl iodides. This bench-stable copper complex converts aryl iodides into their corresponding CF3 derivatives in high yields within 1 h. The protocol is also well-suited for aromatic [18F]trifluoromethylation, offering a rapid and efficient approach for the development of new radiopharmaceuticals within 20 min.

Affiliations

Ji Young Choi 1, Ewa Pietrasiak 2, Nakeun Ko 2, Seok-Yong Lee 3 4, Hyewon Youn 3 4, Jaelim Kim 2, Eunsung Lee 5, Byung Chul Lee 1 6
1Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam 13620, Republic of Korea.
2Department of Chemistry, Pohang University of Science and Technology, Pohang 37673, Republic of Korea.
3Department of Nuclear Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
4Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
5Department of Chemistry, Seoul National University, Seoul 08826, Republic of Korea.
6Department of Applied Bioengineering, Seoul National University, Suwon 16229, Republic of Korea.