방사선의학 웹진

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Abstract
N-Methyl-D-aspartate receptor (NMDAR)-antibody-labeled mesoporous silica nanoparticles (NMDAR-PEG-DID@MSNs) were developed as a fluorescence imaging tool for M1 macrophage-associated inflammatory diseases. The nanoparticles were synthesized by conjugating NMDAR antibodies, polyethylene glycol (PEG), and the fluorescent dye DID onto mesoporous silica nanoparticles. Their imaging capability was evaluated in chronic (turpentine induced) and acute (lipopolysaccharide and carrageenan-induced) inflammation models, as well as for monitoring the anti-inflammatory effects of dexamethasone. NMDAR-PEG-DID@MSNs enabled the early detection of inflamed lesions, with fluorescence signals persisting for up to 24 hours, and successfully demonstrated the therapeutic efficacy of dexamethasone. These results highlight the potential of this nanoplatform for inflammation diagnosis and therapeutic monitoring.

Affiliations

Sang Bong Lee 1 2 3, Hui-Jeon Jeon 4 5, Dinesh Kumar 6, Hoon Hyun 2 3, Yong Hyun Jeon 7 8
1SimVista. Inc, A-13, 194-25, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju-si, Chungcheongbuk-do, Republic of Korea.
2Department of Biomedical Sciences, Chonnam National University Medical School 264, Hwasun-eup, Hwasun 58128, Republic of Korea. hhyun@jnu.ac.kr.
3BioMedical Sciences Graduate Program (BMSGP), Chonnam National University, Hwasun 58128, Republic of Korea.
4New Develop Drug Center, K-medi hub, 80 Cheombok-ro Dong-gu Daegu, Republic of Korea.
5Advanced College of Bio-convergence Engineering, Ajou University, Suwon 16499, South Korea.
6Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 54896, Republic of Korea.
7Laboratory Animal Center, K-medi hub, 80 Cheombok-ro Dong-gu Daegu, Republic of Korea. Jeon9014@kmedihub.re.kr.
8Department of Biotechnology, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu 41566, Republic of Korea.