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Abstract
We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope 64Cu may act as a contrast agent being a diagnostic tool for PET as well as a good T2 MRI nanoprobe due to their good r2/r1 ratio. Furthermore, we demonstrate that the 64Cu incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.

Affiliations

Hye Min Jang 1 2, Myung Hwan Jung 1, Jae Sang Lee 1, Jun Sig Lee 3, In-Cheol Lim 3, Hyunsik Im 2, Sang Wook Kim 4, Sung-A Kang 5, Won-Je Cho 1, Jun Kue Park 1
1Korea Multi-Purpose Accelerator Complex, Korea Atomic Energy Research Institute, 181 Mirae-ro, Gyeongju 38180, Korea.
2Division of Physics and Semiconductor Science, Dongguk University, Seoul 04620, Korea.
3Korea Atomic Energy Research Institute, Daedeok-daero 989, Daejeon 34057, Korea.
4Department of Advanced Materials Chemistry, Dongguk University, Gyeongju 38066, Korea.
5Advanced Bio Convergence, Pohang Technopark, Pohang 37668, Korea.