KAERI / 이준영, 박정훈*
Abstract
64Cu and 67Cu are theragnostic pair radionuclides with promising application in the nuclear medicine. 64Cu is PET nuclide for the non-invasive diagnosis and 67Cu is beta emitter for therapy of various cancers. This study discusses optimization efforts in the production of these radioactive coppers carried out with 30 MeV cyclotron. Optimized conditions include target preparation, chemical separation, and quality control. The production routes of 64Cu and 67Cu were studied based on the nuclear reactions of 64Ni(p,n)64Cu and 70Zn(p,α)67Cu. The produced 64Cu and 67Cu have >99.9% of the radionuclidic purity. The yield at the end of bombardment (EOB) of 64Cu and 67Cu is 28.5 MBq/μAh and 67Cu is 0.58 MBq/μAh, respectively.
Affiliation
Jun Young Lee 1 , Jung Ho Chae 1 , Min Goo Hur 1 , Seung Dae Yang 1 , Young Bae Kong 1 , Jongchul Lee 1 , Jin Sik Ju 1 , Pyeong Seok Choi 1 , Jeong Hoon Park 1
1 Accelerator and Radioisotope Development Team, Korea Atomic Energy Research Institute, Daejeon, South Korea.
편집위원
Cu-64는 핵의학 PET 영상 진단을 위한 방사성동위원소이고, Cu-67은 베타선을 이용한 방사선치료용 방사성동위원소이다. 이 논문은 30 MeV 싸이클로트론을 이용하여 이 두 방사성동위원소의 안정적인 생산을 위한 최적화 과정 및 그 결과를 보여주었다.
2022-06-23 14:25:57