KIRAMS / 강경준, 오세종, 최재용*
Abstract
Background: Micro-positron emission tomography (micro-PET), a small-animal dedicated PET system, is used in biomedical studies and has the quantitative imaging capabilities of radiotracers. A single-bed system, commonly used in micro-PET, is laborious to use in large-scale studies. Here, we evaluated the image qualities of a multi-bed system. Methods: Phantom imaging studies were performed to assess the recovery coefficients (RCs), uniformity, and spill-over ratios (SORs) in water- and air-filled chambers. 18F-FDG and 18F-FPEB PET images of xenograft and normal mice from the multi-bed and single-bed systems were compared. Results: For small diameters (< 3 mm), the RC values between the two systems differed significantly. However, for large diameters (> 4 mm), there were no differences in RC values between the two systems. Uniformity and SORs of both systems were within the tolerance limit of 15%. In the oncological study, the estimation of 18F-FDG uptake in the tumor was significantly lower in the multi-bed system than that in the single-bed system. However, 18F-FDG PET in xenograft mice with tumor size > 4 mm revealed the variation between subjects within the multi-bed system group to be less than 12%. In the neurological study, SUV for the multi-bed group was 25–26% lower than that for the single-bed group; however, inter-object variations within the multi-bed system were below 7%. Conclusions: Although the multi-bed system showed lower estimation of radiotracer uptake than that of the single-bed system, the inter-subject variations were within acceptable limits. Our results indicate that the multi-bed system can be used in oncological and neurological studies.
Affiliations
Kyung Jun Kang 1,†, Se Jong Oh 1,† , Kyung Rok Nam 1, Heesu Ahn 1,2, Ji-Ae Park 1,2 , Kyo Chul Lee 1 and Jae Yong Choi 1,2,*
1 Division of Applied RI, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Korea
2 Radiological and Medico-Oncological Sciences, University of science and technology (UST), Seoul 01812, Korea
* Author to whom correspondence should be addressed.
† These authors contributed equally to this work.
편집위원
일반적으로 동물영상장비는 single bed로 구성되어있기 때문에 한 번에 한 마리 촬영만 가능하다. 따라서 많은 수의 동물 촬영이 필요한 연구에서는 시간적 제약이 항상 문제가 될 수 밖에 없다. 이 논문은 Mediso PET 소동물 영상장비의 single bed 시스템과 소동물 4 마리를 한번에 촬영할 수 있는 multi-bed 시스템을 두 방사성의약품([F-18]FDG & [F-18]FPEB)을 이용해서 효용성을 비교/분석한 후 그 결과를 제시하고 있다.
2021-03-30 11:37:59