한양대, 부산대병원, 부산대 / 김소담, 임상구, 최성용*, 김근영*, 양승윤*
Abstract
Nuclear medicine is a routine but essential clinical option for diagnostic imaging and disease treatment. Encapsulating radioisotopes in injectable biodegradable hydrogels is ideal for localizing radiation sources to target tissues or organs to achieve long-term, low-dose radiotherapy. However, difficulties in the on-site production of radioactive gels upon treatment and the unpredictable radiation level at the target region are major obstacles to their clinical use. In this study, we bypassed these limitations by developing locally injectable hydrogel microparticles based on 131I-labeled photo-crosslinkable hyaluronic acid (HA) and a microfluidic high-throughput droplet generator. This approach enabled rapid on-site production of injectable, radioactive, biodegradable (IRB) HA microgels, thus allowing their immediate therapeutic application with improved local retention and predictable radioactivity. We demonstrated the clinical utility of this comprehensive approach by preparing IRB HA microgels within 15 min and localizing them to the target tissue (rat muscle) with minimal off-target biodistribution and in vivo radioactivity that extended beyond 3 weeks.
연구팀이 개발한 동위원소가 표지된 방사성 마이크로젤 제작 개념도. 의료 현장에서 바로 제조하여 원하는 부위에 주사기로 주입가능하고 3주 이상 원하는 부위에서만 치료효과를 볼 수 있음.
Affiliations
Sodam Kim 1, Sang-Gu Yim 1, Ajeesh Chandrasekharan 1, Keum-Yong Seong 1, Tae Wook Lee 1, Byeongyeon Kim 2, Keunyoung Kim 3, Sungyoung Choi 4, Seung Yun Yang 5
1Department of Biomaterials Science, Pusan National University, Miryang 50463, Republic of Korea.
2Department of Biomedical Engineering, Hanyang University, Seoul 04763, Republic of Korea.
3Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea. Electronic address: kkim_nm@pusan.ac.kr.
4Department of Biomedical Engineering, Hanyang University, Seoul 04763, Republic of Korea. Electronic address: sungyoung@hanyang.ac.kr.
5Department of Biomaterials Science, Pusan National University, Miryang 50463, Republic of Korea. Electronic address: syang@pusan.ac.kr.