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  • Co-delivery of paclitaxel and gemcitabine via CD44-targeting nanocarriers as a prodrug with synergistic antitumor activity against human biliary cancer.

    (연세대: 노일구, 함승주*)

  • 출처
    Biomaterials
  • 등재일
    2015 Jun
  • 저널이슈번호
    53:763-74
  • 내용

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    [Abstract]

    Multi-drug delivery focuses on different signaling pathways in cancer cells that have synergistic anti-proliferative effects. In this study, we developed multi-prodrug nanocarriers (MPDNCs) consisting of poly (l-lysine)-carboxylate PTX (PLL-PTX) and hyaluronic acid-conjugated GEM (HA-GEM) for CD44-targeted synergistic biliary cancer therapy. An in vitro study of cell viability and mRNA expression levels and an in vivo study showed that MPDNCs more effectively inhibit proliferation in CD44-overexpressing cancer cells (HuCCT1) than in cells with lower CD44 expression (SCK) by synergistically inducing apoptosis. Consequently, these results demonstrate that MPDNCs are prodrugs with synergistic cancer therapeutic efficacy and effective cellular uptake at target cells compared to free drugs, indicating their strong potential as efficient multi-drug-carrying nano-platforms for cancer treatment.

    Copyright © 2015 Elsevier Ltd. All rights reserved.

    KEYWORDS:

     

    [Author information]

    Noh I1, Kim HO2, Choi J3, Choi Y4, Lee DK5, Huh YM6, Haam S7.

    1 Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, South Korea; Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, South Korea.

    2 Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, South Korea.

    3 Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, South Korea; Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.

    4 Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul 120-752, South Korea.

    5 Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 135-720, South Korea.

    6 Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul 120-752, South Korea. Electronic address: ymhuh@yuhs.ac.

    7 Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 120-749, South Korea. Electronic address: haam@yonsei.ac.kr.

     

  • 키워드
    Biliary cancer; CD44 targeting; Combined cancer therapy; Gemcitabine; Paclitaxel; Polymeric prodrug
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