KIRAMS / 조휘문, 김천호*
Abstract
Lysyl oxidase (LOX) is a cell-secreted amine oxidase that crosslinks collagen and elastin in extracellular microenvironment. LOX-traceable nanoparticles (LOXab-NPs) consisting of LOX antibodies (LOXab) and paclitaxel, can accumulate at high concentrations at radiation-treated target sites, as a tumor-targeting drug carrier for chemotherapy. Tumor-targeting and anticancer effects of PLGA based LOXab-NPs in vitro and in vivo were evaluated at radiation-targeted site. In the in vivo A549 lung carcinoma xenograft model, we showed highly specific tumor targeting (above 7.0 times higher) of LOXab-NPs on irradiated tumors. Notably, systemically administered NPs delayed tumor growth, reducing tumor volumes by more than 2 times compared with non-irradiated groups (222% vs. >500%) over 2 weeks. Radiotropic LOXab-NPs can serve as chemotherapeutic vehicles for combined targeted chemo-radiotherapy in clinical oncology.
Affiliations
Wheemoon Cho 1 , Min Sup Kim 2 , Kee-Ho Lee 3 , Sang Jun Park 2 , Hyun-Jin Shin 3 , Yong Jin Lee 4 , Sang Bum Kim 5 , Youngsook Son 6 , Chun-Ho Kim 7
1 Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea; Department of Genetic Engineering, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Yongin, Republic of Korea.
2 Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
3 Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
4 Division of RI-Convergence Research, Korea Institute of Radiological & Medical Sciences, Seoul, Republic of Korea.
5 Department of Surgery, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea.
6 Department of Genetic Engineering, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Yongin, Republic of Korea.
7 Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea. Electronic address: chkim@kcch.re.kr.
편집위원
Nanoparticles을 활용하여 radiation에 반응하는 tumor target을 찾을 수 있는 방법을 제시한 흥미로운 논문이라고 사료됨.
2021-01-26 15:21:37