방사선의학 웹진

바로가기  >

Abstract
Objective.TOPAS-nBio enables users to simulate dose rate-dependent radiation chemical yields in water radiolysis accounting for inter-track and long-term chemistry for pulsed irradiation. This study aims to extend the TOPAS-nBio chemistry for the special case of continuous high-dose rate scenario, where both intertrack and longer time reactions need to be considered, and to quantitatively validate the extended framework by comparing the results with experimental data.Approach.The inter-track chemistry and escapeG-values were first evaluated by the independent reaction time method. The escaping molecules were assumed to have a temporally continuous distribution based on theG-values using the Gillespie algorithm. The simulation results were comprehensively validated by comparing with the experimental data at different dose rates, temporal pulse shapes, and solutions. In addition, the influence of various factors, such as the chemistry model, simulation volume, temperature, pH concentration, and organic carbon contamination, was evaluated.Main results.The validation results showed that the H2O2concentration and O2consumption increased with dose rate, and agreed within 3% with experimental data. Computational factors related to the chemistry model and volume size were negligible. pH and temperature had an impact of less than 10% in the experimental range. The presence of organic carbon and resulting reactions doubled H2O2yields and significantly increased O2consumption by about an order of magnitude at lower dose rates, while the results are almost unchanged at higher dose rates. Consequently, the dose rate dependence of H2O2yields and O2consumption were reversed at a certain organic carbon concentration compared to the pure water results.Significance.The extended TOPAS-nBio chemistry framework enables the reproduction of the dose-rate dependent radiation chemical yields of several experimental studies at different dose rates, temporal pulse shapes, and solutions. This new functionality is necessary to investigate recent high dose rate (FLASH) experimental results.

Affiliations

Wook-Geun Shin 1, J Naoki D-Kondo 2, José Ramos-Méndez 2, Jay A LaVerne 3, Bethany Rothwell 1, Alejandro Bertolet 1, Aimee McNamara 4, Bruce Faddegon 2, Harald Paganetti 1, Jan Schuemann 1
1Physics Division, Department of Radiation Oncology, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, United States of America.
2Department of Radiation Oncology, University of California San Francisco Comprehensive Cancer Center, San Francisco, CA 94115, United States of America.
3Radiation Laboratory and Department of Physics and Astronomy, University of Notre Dame, Notre Dame, IN 46556, United States of America.
4Radformation Inc, 261 Madison Ave, 9th Floor, New York, NY 10017, United States of America.