방사선의학 웹진

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Abstract
Background: With the evolving treatment paradigms for pancreatic cancer, there is an increasing need for reliable markers to evaluate the effectiveness of preoperative chemotherapy. Due to the limitations of current indicators, this study aimed to evaluate the prognostic value of metabolic response based on the changes in the maximum standardized uptake value (SUVmax) on fluorine-18-fluorodeoxyglucose positron emission tomography.

Methods: This study included 210 patients with pancreatic cancer who underwent post-chemotherapy curative surgery between 2013 and 2022. Using maximally selected rank statistics for survival, the metabolic response was defined as follows: metabolic responder (%ΔSUVmax >75%), metabolic stable disease (15%-75%), and metabolic non-responder (≤15%).

Results: Among patients, 15.7%, 66.7%, and 11.6% were categorized into the metabolic responder, metabolic stable disease, and metabolic non-responder groups. The metabolic responder group (83.0 months) had longer median overall survival than the metabolic stable disease (51.0 months, p = .013) and metabolic non-responder (32.0 months, p = .002) groups. In addition, being metabolic responders (vs. non-responders) was an independent predictor of low recurrence rates (hazard ratio [95% confidence interval]: 0.46 [0.23-0.91]; p = .026) and achieving pathologic complete response (odds ratio [95% confidence interval]: 13.39 [1.61-300.77]; p = .035).

Conclusions: Metabolic response during preoperative chemotherapy has predictive power for post-resection prognosis and residual tumor status.

Affiliations

Won-Gun Yun 1, Tae Young Kim 2, Seulah Park 1, Youngmin Han 1, Go-Won Choi 1, Hye-Sol Jung 1, Wooil Kwon 1, Joon Seong Park 1, Gi Jeong Cheon 2 3 4, Jin-Young Jang 1
1Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.
3Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
4Cancer Research Institute & Institute on Aging, Seoul National University, Seoul, Republic of Korea.