방사선의학 웹진

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Abstract
Objectives: We aimed to evaluate correlations between striatal dopamine transporter (DAT) uptake and clinical assessments in both patients with Parkinson's disease (PD) and healthy controls.

Methods: This study enrolled 193 healthy controls, and 581 patients with PD. They underwent various clinical assessments and 123I-FP-CIT SPECT scans. After reconstruction, attenuation correction, and normalization of SPECT images, counts were measured from the bilateral caudate and putamen, and the occipital cortex for reference. Count densities for each region were extracted and used to calculate striatal binding ratios (SBRs) for each striatal region. SBR is calculated as (target region/reference region)-1. After logarithmic transformation of striatal SBRs, we analyzed the effects of clinical assessments on striatal SBRs using Bayesian hierarchical modeling.

Results: MDS-UPDRS total score, part I, part II, part III, Epworth Sleepiness Scale, REM sleep behavior disorder screening questionnaire, SCOPA-AUT total score were negatively associated with striatal SBR in patients with PD. Also, HVLT recognition discrimination was positively associated with striatal SBR in both healthy controls and patients with PD. In healthy control, MDS-UPDRS part II, MOCA, SCOPA-AUT total score were positively associated with striatal SBR.

Conclusion: We demonstrated that motor symptom, sleep disturbance, autonomic symptom, and cognition of patients with PD were associated with striatal dopaminergic activity. In healthy controls, motor symptoms, autonomic symptom, and cognition were associated with striatal dopaminergic activity, some of which showing the opposite direction with patients with PD. This result might provide new insight to underlying mechanism of dopamine system with motor and non-motor assessments.

그림 설명 – SCOPA-AUT 자율신경계 점수와 DAT의 관계

좌측. 정상인

우측. 파킨슨병 환자

Affiliations

Seunghyeon Shin 1, Hyun-Yeol Nam 1, Keunyoung Kim 2 3, Jihyun Kim 2, Myung Jun Lee 3 4, Kyoungjune Pak 5 6
1Department of Nuclear Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, 179 Gudeok-Ro, Seo-Gu, Busan, 49241, Republic of Korea.
2Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
3School of Medicine, Pusan National University, Busan, Republic of Korea.
4Department of Neurology and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
5Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. ilikechopin@me.com.
6School of Medicine, Pusan National University, Busan, Republic of Korea. ilikechopin@me.com.