핵의학

본문글자크기
  • [Life (Basel) .] Relationship of FDG Uptake of the Reticuloendothelial System with Tumor Immune Microenvironment and Prognosis in Patients with Gastric Cancer

    순천향대천안병원, 가톨릭관동대 / 안혜인, 송금종, 이상미*, 이정원*

  • 출처
    Life (Basel) .
  • 등재일
    2023 Mar 13
  • 저널이슈번호
    13(3):771. doi: 10.3390/life13030771.
  • 내용

    바로가기  >

    Abstract
    2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake of the reticuloendothelial system, including the bone marrow (BM) and spleen, on positron emission tomography/computed tomography (PET/CT) has been shown to be a significant prognostic factor in diverse malignancies. However, the relationship between FDG uptake of the BM and spleen and histopathological findings, including the tumor immune microenvironment, has not been fully evaluated. This study aimed to investigate the relationship of FDG uptake in the BM and spleen with histopathological findings and recurrence-free survival (RFS) in patients with gastric cancer. Seventy patients with gastric cancer who underwent pre-operative FDG PET/CT and subsequent curative surgery were retrospectively enrolled. On image analysis, the BM-to-liver uptake ratio (BLR) and spleen-to-liver uptake ratio (SLR) were measured from PET/CT images, and on immunohistochemical analysis, the densities of immune cell infiltration in the tumor tissue were graded. The BLR and SLR showed significant positive correlations with the grades of CD163 cell and CD8 cell infiltration in the tumor tissue, respectively (p < 0.05). In multivariate survival analysis, both BLR and SLR were significant predictors of RFS (p < 0.05). FDG uptake in the BM and spleen might be potential imaging biomarkers for evaluating tumor immune microenvironment conditions and predicting RFS in patients with gastric cancer.

     

     

    Affiliations

    Hyein Ahn 1, Geum Jong Song 2, Moon-Soo Lee 2, Ji-Hye Lee 1, Si-Hyong Jang 1, Mee-Hye Oh 1, Jong Hyuk Yun 2, Sang Mi Lee 3, Jeong Won Lee 4
    1Department of Pathology, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea.
    2Department of Surgery, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea.
    3Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea.
    4Department of Nuclear Medicine, College of Medicine, Catholic Kwandong University, International St. Mary's Hospital, 25 Simgok-ro 100-gil, Seo-gu, Incheon 22711, Republic of Korea.

  • 키워드
    F-18 fluorodeoxyglucose; bone marrow; positron emission tomography; prognosis; spleen; stomach neoplasm.
  • 편집위원

    골수, 비장을 포함한 세망내피계(reticuloendothelial system)의 F-18 FDG PET/CT 섭취 영상은 다양한 악성 종양에서 중요한 예후 인자이지만 골수, 비장 섭취와 종양 면역 미세환경을 포함하는 조직 병리학적 소견과의 관계는 완전히 평가되지 않고 있다. 이 연구는 위암환자에서 F-18 FDG 골수, 비장 섭취와 조직 병리학적 소견 및 무재발 생존의 관계성을 조사한 것으로, F-18 FDG PET/CT는 위암 환자의 무재발 생존을 예측하기 위한 생체 영상 바이오마커로 활용될 수 있다는 결과를 제시하고 있다.

    2023-05-08 16:59:46

  • 덧글달기
    덧글달기
       IP : 3.88.16.192

    등록