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Abstract
Hair loss is one of the most common disorders that affect both male and female patients. Cell-derived nanovesicles (CDVs) are natural extracellular vesicles and engineered nanovesicles that can carry various biologicals materials such as proteins, lipids, mRNA, miRNA, and DNA. These vesicles can communicate with local or distant cells and are capable of delivering endogenous materials and exogenous drugs for regenerative therapies. Recent studies revealed that CDVs can serve as new treatment strategies for hair growth. Herein, we review current knowledge on the role of CDVs in applications to hair growth. The in-depth understanding of the mechanisms by which CDVs enable therapeutic effects for hair growth may accelerate successful clinical translation of these vesicles for treating hair loss.

Affiliations

Prakash Gangadaran  1   2 , Ramya Lakshmi Rajendran  1 , Mi Hee Kwack  2   3 , Madhan Jeyaraman  4   5   6 , Chae Moon Hong  1   7 , Young Kwan Sung  2   3 , Byeong-Cheol Ahn  1   2   7
1 Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
2 BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu, South Korea.
3 Department of Immunology, School of Medicine, Kyungpook National University, Daegu, South Korea.
4 Department of Orthopaedics, Faculty of Medicine, Sri Lalithambigai Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai, India.
5 Department of Biotechnology, School of Engineering and Technology, Sharda University, Noida, India.
6 Indian Stem Cell Study Group (ISCSG) Association, Lucknow, India.
7 Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu, South Korea.