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  • [Front Oncol.] A Nomogram for Predicting Pathological Complete Response to Neoadjuvant Chemoradiotherapy Using Semiquantitative Parameters Derived From Sequential PET/CT in Locally Advanced Rectal Cancer

    성균관의대 / 표대희, 최준영, 조용범*

  • 출처
    Front Oncol.
  • 등재일
    2021 Oct 5
  • 저널이슈번호
    11:742728. doi: 10.3389/fonc.2021.742728. eCollection 2021.
  • 내용

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    Abstract
    We evaluated the predictive value of semiquantitative volumetric parameters derived from sequential PET/CT and developed a nomogram to predict pathological complete response (pCR) in patients with rectal cancer treated by neoadjuvant chemoradiotherapy (nCRT). From April 2008 to December 2013, among the patients who underwent nCRT, those who were taken sequential PET/CT before and after nCRT were included. MRI-based staging and semiquantitative parameters of PET/CT including standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were evaluated before and after nCRT. Multivariable analysis was performed to select significant predictors to construct a nomogram. Sensitivity, specificity, accuracy, and area under the receiver operating characteristics curve (AUC) of the model were evaluated to determine its performance. Among 137 eligible patients, 17 (12.4%) had pCR. All post-PET/CT parameters showed significant differences between pCR and non-pCR groups. Patients were randomly assigned to a training group (91 patients) and a validation group (46 patients). In multivariable analysis with the training group, post-CEA, post-MRI T staging, post-SUVmax, and post-MTV were significantly associated with pCR. There was no significant pre-nCRT variable for predicting pCR. Using significant predictors, a nomogram was developed. Sensitivity, specificity, accuracy, and AUC of the nomogram were 0.882, 0.808, 0.848, and 0.884 with the training group and 0.857, 0.781, 0.783, and 0.828 with the validation group, respectively. This model showed the better performance than other predictive models that did not contain PET/CT parameters. A nomogram containing semiquantitative post-PET/CT could effectively select candidates for organ-sparing strategies.

     

     

    Affiliations

    Dae Hee Pyo  1 , Joon Young Choi  2 , Woo Yong Lee  1   3 , Seong Hyeon Yun  1 , Hee Cheol Kim  1 , Jung Wook Huh  1 , Yoon Ah Park  1 , Jung Kyong Shin  1 , Yong Beom Cho  1   3   4
    1 Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    2 Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    3 Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Seoul, South Korea.
    4 Department of Biopharmaceutical Convergence, Sungkyunkwan University, Seoul, South Korea.

  • 키워드
    PET/CT; locally advanced rectal cancer (LARC); neoadjuvant chemoradiotherapy; nomogram; pathological complete response (pCR).
  • 편집위원

    Nomogram과 breast peritumoral adipose tissue parameter를 이용한 연구들로, 현재 진행중인 암종의 치료반응과 예후와 관련된 연구에 많은 참고가 되어 개인적으로 흥미롭습니다.

    2021-12-06 16:02:33

  • 편집위원

    Nomogram과 breast peritumoral adipose tissue parameter를 이용한 연구들로, 현재 진행중인 암종의 치료반응과 예후와 관련된 연구에 많은 참고가 되어 개인적으로 흥미롭습니다.

    2021-12-06 16:03:30

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