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Abstract
Co-occurring depression and mild cognitive impairment (MCI) in older adults are important because they have a high risk of conversion to dementia. In the present study, task-related F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) was used to analyse older adults with concomitant depression and MCI. We recruited 20 older adults with simultaneous depression and MCI and 10 older adults with normal cognition (NC). The Verbal Paired Associates test and digit span test were used for the task-related FDG-PET. The 20 older adults with depression and MCI were classified into two groups based on the F-18 florbetaben PET results: depressed MCI patients with (LLD-MCI-A[+]; n = 11) and without amyloid accumulation (LLD-MCI-A[-]; n = 9). Reduced regional cerebral glucose metabolism (rCMglc) in the left superior frontal region was observed in the LLD-MCI-A(-) group compared with the NC group. Analyses of the NC and LLD-MCI-A(+) groups showed significantly decreased rCMglc in the right inferior parietal and left middle frontal regions in the LLD-MCI-A(+) group. rCMglc in the left precuneus was lower in the LLD-MCI-A(+) group than in the LLD-MCI-A(-) group. Significant correlations between the rCMglc in the right inferior parietal/left precuneus regions and memory task scores were observed based on correlation analyses of NC and LLD-MCI-A(+) groups. The findings in the present study indicate the presence of amyloid accumulation influences glucose metabolism in depressed elderly subjects with MCI while performing cognitive tasks. Task-related FDG-PET examinations may help differentiate MCI associated with depression from comorbid depression in patients with prodromal Alzheimer's disease.

Affiliations

Eun Seong Lee  1 , HyunChul Youn  2 , Won Seok William Hyung  3 , Sangil Suh  4 , Cheol E Han  5 , Jae Seon Eo  1 , Hyun-Ghang Jeong  3   6
1 Department of Nuclear Medicine, Korea University Guro Hospital, Seoul, South Korea.
2 Department of Psychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea.
3 Department of Psychiatry, Korea University Guro Hospital, Seoul, South Korea.
4 Department of Radiology, Korea University Guro Hospital, Seoul, South Korea.
5 Department of Electronics and Information Engineering, Korea University, Sejong, South Korea.
6 Korea University Research Institute of Mental Health, Seoul, South Korea.