핵의학

본문글자크기
  • [Biomed Pharmacother .] Effects of oligonol on the submandibular gland in ovariectomized rats

    부산대병원 / 김정훈, 이병주*, 김근영*

  • 출처
    Biomed Pharmacother .
  • 등재일
    2021 Sep
  • 저널이슈번호
    141:111897. doi: 10.1016/j.biopha.2021.111897. Epub 2021 Jul 12.
  • 내용

    바로가기  >

    Abstract
    The aim of this study was to observe the effects of oligonol on submandibular gland dysfunction in ovariectomized rats. We randomly divided female Sprague-Dawley rats into sham-operated, ovariectomized, and oligonol-treated ovariectomized groups. Oligonol was intraperitoneally administered at 30 mg/kg daily for six weeks. Lipogenesis increased after the ovariectomy while fatty acid oxidation increased and intracellular triglyceride levels decreased in response to oligonol treatment. Submandibular gland fibrosis characterized by collagen type I accumulation was observed in the ovariectomized group. However, oligonol markedly reduced fibrosis to a level comparable to that observed in the sham group. Aquaporin 1 and glucose transporter 4 were downregulated in the ovariectomized group. Nevertheless, both factors were significantly upregulated by oligonol treatment. However, aquaporin 5 was significantly downregulated in the oligonol treatment group. Our findings indicate that oligonol protects against damage in postmenopausal rat salivary glands.

     

     

    Affiliations

    Jeong Hun Kim 1, Hyangkyu Lee 2, Ji Min Kim 3, Hyung-Sik Kim 4, Sung-Chan Shin 5, Sun-Kyung Hwang 6, Byung-Joo Lee 7, Keunyoung Kim 8
    1Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea.
    2Yonsei University College of Nursing, Mo-Im Kim Nursing Research Institute, Seoul 03722, Republic of Korea.
    3Pusan National University Medical Research Institute, Pusan National University School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea.
    4Department of Life Science in Dentistry, School of Dentistry, Pusan National University, Yangsan 50612, Republic of Korea.
    5Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Pusan National University, Busan 49241, Republic of Korea.
    6College of Nursing, Pusan National University, Yangsan 50612, Republic of Korea.
    7Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea; Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Pusan National University, Busan 49241, Republic of Korea. Electronic address: voiceleebj@gmail.com.
    8Biomedical Research Institute, Pusan National University Hospital, Busan 49241, Republic of Korea; Department of Nuclear Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea. Electronic address: nmpnuh@gmail.com.

  • 키워드
    Aquaporin; Oligonol; Ovariectomy; Submandibular gland; Xerostomia.
  • 덧글달기
    덧글달기
       IP : 54.159.116.24

    등록