서울의대, 서울특별시보라매병원 / 신정환, 이지영*, 김유경*
Abstract
Objective: To elucidate the role of Parkinson's disease (PD)-related brain metabolic patterns as a biomarker in isolated rapid-eye-movement sleep behavior disorder (iRBD) for future disease conversion.
Method: This is a prospective cohort study consisting of 30 iRBD patients, 25 de novo PD patients with a premorbid history of RBD, 21 long-standing PD patients on stable treatment and 24 healthy controls. iRBD group was longitudinally followed up. All participants underwent 18F-Fluorodeoxyglucose (FDG) PET and were evaluated with olfaction, cognition, and the Movement disorders society-Unified PD Rating Scale (MDS-UPDRS) at baseline. From FDG-PET scans, we derived metabolic patterns from the long-standing PD group (PD-RP) and de novo PD group with RBD (dnPDRBD-RP). Subsequently, we calculated the PD-RP and dnPDRBD-RP scores in iRBD patients. We validated the metabolic patterns in each PD group and separate iRBD cohort (n=14).
Result: The two patterns significantly correlated with each other and were spatially overlapping yet distinct. The MDS-UPDRS motor scores significantly correlated with PD-RP (p = 0.013) but not with dnPDRBD-RP (p = 0.076). In contrast, dnPDRBD-RP correlated with olfaction in butanol threshold test (p = 0.018) in iRBD subjects, but PD-RP did not (p = 0.21). High dnPDRBD-RP in iRBD patients predicted future phenoconversion with all cut-off ranges from 1.5 to 3 standard deviations of the control value, whereas predictability of PD-RP was only significant in a partial range of cut-off.
Conclusion: The dnPDRBD-RP is an efficient neuroimaging biomarker that reflects prodromal features of PD and predicts phenoconversion in iRBD that can be applied individually.
Affiliations
Jung Hwan Shin 1 , Jee-Young Lee 2 , Yu-Kyeong Kim 3 , Eun Jin Yoon 4 , Heejung Kim, Hyunwoo Nam 1 , Beomseok Jeon 5
1 Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center & Seoul National University College of Medicine, Seoul, South Korea.
2 Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center & Seoul National University College of Medicine, Seoul, South Korea wieber04@snu.ac.kr yk3181@snu.ac.kr.
3 Department of Nuclear medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea wieber04@snu.ac.kr yk3181@snu.ac.kr.
4 Department of Nuclear medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea.
5 Department of Neurology, Seoul National University Hospital & Seoul National University College of Medicine, Seoul, South Korea.