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  • [Ann Nucl Med.] Test-retest reproducibility of dopamine transporter density measured with [ 18 F]FP-CIT PET in patients with essential tremor and Parkinson's disease

    울산의대 / 손혜주, 김재승*

  • 출처
    Ann Nucl Med.
  • 등재일
    2021 Mar
  • 저널이슈번호
    35(3):299-306. doi: 10.1007/s12149-020-01561-9. Epub 2021 Jan 2.
  • 내용

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    Abstract
    Objective: 18F-labeled fluoropropyl-carbomethoxylodopropyl-nor-ß-tropane ([18F]FP-CIT) positron emission tomography (PET) is a useful tool for evaluating disease progression in Parkinson's disease (PD) patients. We evaluated the test-retest reproducibility of [18F]FP-CIT PET measures in essential tremor (ET) and PD patients.

    Methods: Fifteen ET (68.9 ± 6.6 years) and 10 PD patients (70.5 ± 6.3 years; Hoehn and Yahr stage, 2.3 ± 0.8) underwent two [18F]FP-CIT PET/CT scans with an interval of 48 ± 7 day. For both the test and retest studies, standardized uptake value ratios were estimated for 90-min and 3-h acquisitions for the caudate, anterior putamen, and posterior putamen using T1-MRI-based normalization (automatic) and fixed-VOI (manual) methods, with the occipital lobe as a reference. Reproducibility was evaluated by the bias, variability, percent test-retest, within-subject coefficient of variation, repeatability coefficient, and intraclass correlation coefficient (ICC).

    Results: Reproducibility was excellent, with low variability (ET: 6.99-8.02%, PD: 3.51-6.94%) and high reliability (ICC; ET: 0.88-0.96, PD: 0.98-0.99). The ET group showed higher variability and lower ICCs than the PD group. The variability in the 90-min images (ET: 7.85-8.59%, PD: 1.52-2.75%) was comparable to that in the 3-h images (ET: 6.99-8.02%, PD: 3.51-6.94%). There were no differences in variability among the subregions in the ET group. In the PD group, the variability was high in the posterior putamen (automatic method: 6.94%, manual method: 11.80%). The test-retest variability and ICCs were similar for the manual and automatic methods.

    Conclusion: [18F]FP-CIT PET is reproducible for the quantitative measurement of DAT binding in both ET and PD individuals, independent of the acquisition time or analysis method. Also, the automatic method is more suitable for evaluating early loss of DAT binding in patients with PD.

     

     

    Affiliations

    Hye Joo Son  1 , Jungsu S Oh  1 , Minyoung Oh  1 , Sang Ju Lee  1 , Seung Jun Oh  1 , Sun Ju Chung  2 , Jae Seung Kim  3
    1 Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    2 Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    3 Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. jaeskim@amc.seoul.kr.

  • 키워드
    Essential tremor; Parkinson’s disease; Reliability; Reproducibility; [18F]FP-CIT PET/CT.
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