성균관의대 / 이주희, 조영석, 최준영*
Abstract
Background: Imaging tumor FDG avidity could complement prognostic implication in thymic epithelial tumors. We thus investigated the prognostic value of volume-based 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/CT parameters in thymic epithelial tumors with other clinical prognostic factors.
Methods: This is a retrospective study that included 83 patients who were diagnosed with thymic epithelial tumors and underwent pretreatment 18F-FDG PET/CT. PET parameters, including maximum and average standardized uptake values (SUVmax, SUVavg), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), were measured with a threshold of SUV 2.5. Univariate and multivariate analysis of PET parameters and clinicopathologic variables for time-to-progression was performed by using a Cox proportional hazard regression model.
Results: There were 21 low-risk thymomas (25.3%), 27 high-risk thymomas (32.5%), and 35 thymic carcinomas (42.2%). Recurrence or disease progression occurred in 24 patients (28.9%). On univariate analysis, Masaoka stage (p < 0.001); histologic types (p = 0.009); treatment modality (p = 0.001); and SUVmax, SUVavg, MTV, and TLG (all p < 0.001) were significant prognostic factors. SUVavg (p < 0.001) and Masaoka stage (p = 0.001) were independent prognostic factors on multivariate analysis.
Conclusion: SUVavg and Masaoka stage are independent prognostic factors in thymic epithelial tumors.
환자 병기와 함께 원발 종양의 체적기반 PET 정량지표인 SUVavg에 따라 환자 예후가 유의하게 달라짐.
Affiliations
Joohee Lee 1 , Young Seok Cho 2 , Jhingook Kim 3 , Young Mog Shim 3 , Kyung-Han Lee 2 , Joon Young Choi 2
1 Department of Nuclear Medicine, CHA Ilsan Medical Center, CHA University, Goyang 10414, Korea.
2 Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
3 Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
편집위원
FDG PET 영상을 이용한 흉선종양의 예후 평가 가능성을 보여준 임상연구임. 비교적 빈도가 낮은 종양의 FDG PET 영상의 임상적 유용성을 잘 보여준 연구임. 핵의학 임상가 및 종양 임상의사에게 FDG PET의 이용 필요성을 제공한 연구로 생각됨.
2021-03-25 16:03:34