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  • [J Cardiovasc Transl Res.] Comparison of High-Dose Rosuvastatin Versus Low-Dose Rosuvastatin Plus Ezetimibe on Carotid Atherosclerotic Plaque Inflammation in Patients with Acute Coronary Syndrome

    울산의대 / 오민영, 이철환*

  • 출처
    J Cardiovasc Transl Res.
  • 등재일
    2020 Dec
  • 저널이슈번호
    13(6):900-907. doi: 10.1007/s12265-020-10009-4.
  • 내용

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    Abstract
    We compared the effects of ezetimibe/rosuvastatin 10/5 mg versus rosuvastatin 20 mg on carotid atherosclerotic plaque inflammation measured by 18FDG PET/CT. Fifty patients with acute coronary syndrome (ACS) were randomly assigned to the ezetimibe/rosuvastatin 10/5 mg and rosuvastatin 20 mg groups. The primary outcome was the percent change in the target-to-background ratio (TBR) of the index vessel in the most diseased segment (MDS), as assessed by 18FDG PET/CT at baseline and at 6 months. Forty-eight patients completed follow-up PET/CT. MDS TBR was - 6.2 ± 13.9% for patients in the ezetimibe/rosuvastatin group and - 10.8 ± 17.7% for those in the rosuvastatin group (difference, 4.6 percentage points; upper limitation of one-sided confidence interval = 13.8; p = 0.60 for noninferiority). In conclusion, combination therapy with ezetimibe 10 mg and rosuvastatin 5 mg compared with rosuvastatin 20 mg did not meet the criterion for non-inferiority for primary outcome, and the present study was not conclusive on whether the former was non-inferior to the latter. Graphical Abstract.

     

     

    Affiliations

    Minyoung Oh  1 , Hyunji Kim  1 , Eon Woo Shin  1 , Changhwan Sung  1 , Do-Hoon Kim  1 , Dae Hyuk Moon  1 , Nayoung Kim  2 , Jae Seon Eo  3 , Jin Won Kim  4 , Cheol Whan Lee  5   6
    1 Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
    2 Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
    3 Department of Nuclear Medicine, Korea University Guro Hospital, Seoul, South Korea.
    4 Cardiovascular Center, Korea University Guro Hospital, Seoul, South Korea.
    5 Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. cheolwlee@amc.seoul.kr.
    6 Division of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, South Korea. cheolwlee@amc.seoul.kr.

  • 키워드
    Ezetimibe; Plaque inflammation; Positron emission tomography; Statin.
  • 편집위원

    FDG PET 영상을 이용한 atherosclerotic plaque의 평가에 하여 항지질요법의 유용성 평가에 이용할 수 있음을 보여준 임상연구임. FDG PET 영상의 임상적 연구 이용 다양성을 잘 보여준 연구임. 핵의학 임상가에게 FDG PET의 이용 방향에 대한 새로운 시각을 제공한 연구로 생각됨.

    2021-01-26 14:55:43

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