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  • [Sci Rep.] Comparison of the prognostic values of 18 F-fluorodeoxyglucose parameters from colon and non-colon sites of involvement in diffuse large B-cell lymphoma of the colon

    [Sci Rep.] Comparison of the prognostic values of 18 F-fluorodeoxyglucose parameters from colon and non-colon sites of involvement in diffuse large B-cell lymphoma of the colon

    성균관의대 / 임채홍, 이경한*

  • 출처
    Sci Rep.
  • 등재일
    2020 Jul 29
  • 저널이슈번호
    10(1):12748. doi: 10.1038/s41598-020-69550-6.
  • 내용

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    Abstract
    We examined the prognostic values of 18F-fluorodeoxyglucose (18F-FDG) parameters from colon, non-colon, and total lesions in patients with diffuse large B-cell lymphoma (DLBCL) of the colon. Positron emission tomography/computed tomography (PET/CT) in 50 patients was retrospectively analyzed for maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG). During follow-up, 13 patients showed progression and 9 died from disease. Receiver operating characteristics (ROC) curve analysis showed that non-colon and total lesion MTV and TLG and colon lesion SUVmax were associated with progression or death. Significant univariate predictors of poor event-free survival (EFS) included stage III-IV, greater International Prognostic Index (IPI) score, no resection, high non-colon lesion SUVmax, MTV and TLG, and high total lesion MTV and TLG. Univariate predictors of poor overall survival (OS) included stage III-IV, greater IPI score, no resection, high non-colon lesion MTV and TLG, high total lesion MTV, and low colon lesion SUVmax. Multivariate analysis revealed that high non-colon lesion TLG was independently associated with poor EFS and OS. Low colon lesion SUVmax was also independently associated with poor OS. In a subgroup with colon-dominant involvement (n = 35), non-colon lesion MTV and TLG were associated with events and non-colon lesion MTV was associated with patient death. Univariate analysis showed that high non-colon lesion MTV was a significant predictor of poor EFS and OS, while non-colon lesion TLG was a significant predictor of poor OS. Thus, volumetric FDG parameters of non-colon lesions offered significant prognostic information in patients with DLBCL of the colon.

     

     

    Colon lymphoma 대표그림 

     

     

    Affiliations

    Chae Hong Lim  1 , Seung Hyup Hyun  2 , Seung Hwan Moon  2 , Young Seok Cho  2 , Joon Young Choi  2 , Kyung-Han Lee  3
    1 Department of Nuclear Medicine, Soonchunhyang University Hospital, Seoul, Korea.
    2 Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea.
    3 Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. khnm.lee@samsung.com.

  • 연구소개
    대장을 침범한 미만성 거대 B세포 림프종 환자를 대상으로 FDG PET/CT에서의 종양 세포의 불소화 포도당 섭취 정도가 환자의 예후에 미치는 영향을 연구한 논문입니다. 특히 대장과 대장 이외의 조직을 침범한 종양 세포간의 포도당 섭취가 갖는 예후적 가치가 다를 수 있음을 밝혔습니다. 이러한 림프종의 조직 침범의 위치에 따른 중요도의 차이는 앞으로의 림프종 연구들에 있어서 새로운 해석의 가능성을 제시할 수 있을 것으로 생각합니다.
  • 편집위원

    대장의 large B cell lymphoma의 FDG PET상 관찰되는 대장외 병변의volumetric FDG PET parameter가 대상 환자의 예후인자임을 찾아냄. 대장암 관련 외과 및 종양학 의사, 핵의학 의사에게 관심을 끌 논문으로 생각됨.

    2020-08-26 13:37:23

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