방사선의학 웹진

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Abstract
Purpose: We compared the local control rate and toxicity of stereotactic ablative radiotherapy (SABR) versus wedge resection for colorectal pulmonary metastases.

Materials and methods: We retrospectively reviewed medical charts and imaging of patients treated with SABR or wedge resection between 2010 and 2017 at a single institution.

Results: A total of 404 patients were treated with local therapy for 528 pulmonary metastatic lesions. While surgery was frequently used upfront for smaller, solitary metastases without other site involvement, SABR was often used for larger, multiple lesions and disease burdens beyond the lungs. The 3-year local control rate was 88.6% following surgery, which was not significantly different from that with SABR at 86.7% (p=0.174). No major postoperative complications or mortality were observed in the surgery group, and 2.8% of patients in the SABR group experienced grade 3-4 radiation pneumonitis.

Conclusion: SABR was used in patients with a higher risk of progression compared to those undergoing surgery, yet it has similar local control rates to wedge resection.

Affiliations

Byung Min Lee 1 2, Ha Eun Kim 3, Young Ho Yang 3, Seung Yoon Yang 4, Han Sang Kim 5, Seo Hee Choi 1, Woong Sub Koom 1, Byung Jo Park 3, Jee Suk Chang 1
1Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
2Department of Radiation Oncology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
3Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Korea.
4Division of Colon and Rectal Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
5Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.