방사선의학 웹진

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Abstract
Background: This study evaluates functional larynx preservation in patients with hypopharyngeal cancer (HPC) and laryngeal cancer (LC) who achieved complete remission following radiotherapy (RT) or concurrent chemoradiation (CCRT).

Methods: HPC and LC patients treated with RT/CCRT from 1999 to 2017 were retrospectively analyzed. Severe late dysphagia and tracheostomy cases were assessed to determine laryngeal function. Long-term preservation rate of functional larynx and associated factors were evaluated.

Results: Of 152 patients (55 HPC, 97 LC), nine developed severe dysphagia, occurring on average 58.2 months post-treatment. HPC and cervical node metastasis significantly increased the risk of laryngeal function impairment (p < 0.001 and p = 0.014, respectively), presenting a continued decline in functional larynx preservation rate beyond 10 years.

Conclusions: Patients with HPC and cervical node metastasis demonstrate an increased risk for long-term laryngeal function impairment despite successful oncologic outcomes. This risk extends beyond 10 years, underscoring the need for prolonged monitoring and comprehensive support.

Affiliations

Gene Huh 1 2, Eun-Jae Chung 2 3, Won Shik Kim 2 3, Seong Keun Kwon 2 3, Myung-Whun Sung 2 3, Bhumsuk Keam 2 4, Hong-Gyun Wu 2 5, Joo Ho Lee 2 5, Jin Ho Kim 2 5, Soon-Hyun Ahn 2 3
1Department of Otorhinolaryngology - Head and Neck Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, South Korea.
2Seoul National University College of Medicine, Seoul, South Korea.
3Department of Otorhinolaryngology - Head and Neck Surgery, Seoul National University Hospital, Seoul, South Korea.
4Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
5Department of Radiation Oncology, Seoul National University Hospital, Seoul, South Korea.