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  • [Sci Rep.] Thirty-year clinical experience in gamma knife radiosurgery for trigeminal schwannomas

    울산의대 / 신동원, 김영훈*

  • 출처
    Sci Rep.
  • 등재일
    2022 Aug 23
  • 저널이슈번호
    12(1):14357. doi: 10.1038/s41598-022-18689-5.
  • 내용

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    Abstract
    We aimed to evaluate the radiographic and clinical outcomes after gamma knife radiosurgery (GKRS) for trigeminal schwannomas (TSs). A total of 87 patients who underwent GKRS for TSs between 1990 and 2020 were enrolled. The mean tumor volume was 4.3 cm3. The median prescribed dose for the margins of the tumor was 13 Gy. The median follow-up duration was 64.3 months (range 12.0-311.5 months). The overall local tumor control rate was 90%, and the symptom response rate was 93%. The response rate for each symptom was 88% for facial pain, 97% for facial sensory change, and 86% for cranial nerve deficits. Nineteen (22%) patients showed transient swelling, which had regressed at the time of the last follow-up. Cystic tumors were associated with transient swelling (p = 0.04). A tumor volume of < 2.7 cm3 was associated with local tumor control in univariable analysis. Transient swelling was associated with symptom control failure in both univariable and multivariable analyses (p = 0.04, odds ratio 14.538). GKRS is an effective treatment for TSs, both for local control and symptom control.

     

     

    Affiliations

    Dong-Won Shin  1   2 , Chunseng Ju  3 , Hyun Seok Lee  1   4 , Hee Jun Yoo  1   5 , Sang Woo Song  1 , Young Hyun Cho  1 , Chang-Ki Hong  1 , Seok Ho Hong  1 , Do Heui Lee  1 , Jeong Hoon Kim  1 , Young-Hoon Kim  6
    1 Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.
    2 Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
    3 Department of Plastic Surgery, Suwon Ever Plastic Surgery Clinic, Suwon, Gyeonggi-do, Republic of Korea.
    4 Department of Neurosurgery, Konkuk University Hospital, Seoul, Republic of Korea.
    5 Department of Neurosurgery, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Gyeonggi-do, Republic of Korea.
    6 Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea. justin527@hanmail.net.

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