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  • [Cancer Res Treat.] Radiotherapy versus Surgery in Early-Stage HPV-Positive Oropharyngeal Cancer

    서울대학교보라매병원 / 김동연, 위찬우*

  • 출처
    Cancer Res Treat.
  • 등재일
    2022 Apr
  • 저널이슈번호
    54(2):406-416. doi: 10.4143/crt.2021.441.
  • 내용

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    Abstract
    Purpose: This study aimed to compare the outcomes of primary radiotherapy (RT) versus surgery in early-stage human papilloma virus-positive oropharyngeal squamous cell carcinoma (hpv+OPC), and investigate the preoperative clinical factors that can predict the requirement for postoperative adjuvant treatment.

    Materials and methods: This multicenter study included 166 patients with American Joint Committee on Cancer 8th edition-Stages I-II hpv+OPC. Sixty (36.1%) and 106 (63.9%) patients underwent primary (concurrent chemo)radiotherapy [(CC)RT] and surgery, respectively. Seventy-eight patients (73.6%) in the surgery group received postoperative (CC)RT.

    Results: With a median follow-up of 45.6 months for survivors, the 2-year overall survival (OS), progression-free survival (PFS), and locoregional control (LC) for RT/surgery were 97.8%/96.4%, 91.1%/92.0%, and 92.9%/93.3%, respectively. In multivariate analyses, patients with synchronous radiologic extranodal extension and conglomeration (ENEcong) of metastatic lymph nodes (LNs) showed significantly poorer OS (p=0.047), PFS (p=0.001), and LC (p=0.003). In patients undergoing primary surgery, two or more clinically positive LN metastases (odds ratio [OR], 5.15; p=0.004) and LN metastases with ENEcong (OR, 3.75; p=0.009) were predictors of postoperative chemoradiotherapy. No patient in the primary RT group demonstrated late severe toxicity whereas three (2.8%), one (0.9%), and one (0.9%) patient in the surgery group showed grade 3 dysphagia, grade 3 xerostomia, and fatal oral cavity bleeding.

    Conclusion: We found no differences in OS, PFS, and LC between upfront RT and surgery in stage I-II hpv+OPC which warrants comparison through a prospective trial in the treatment de-escalation era. However, most early-stage hpv+OPC patients undergoing surgery received adjuvant (CC)RT. Pretreatment LN findings were prognostic and predictive for adjuvant treatment.

     

     

    Affiliations

    Dong-Yun Kim  1 , Hong-Gyun Wu  1 , Jin Ho Kim  1 , Joo Ho Lee  1 , Soon-Hyun Ahn  2 , Eun-Jae Chung  2 , Keun-Yong Eom  3 , Young Ho Jung  4 , Woo-Jin Jeong  4 , Tack-Kyun Kwon  5 , Suzy Kim  6 , Chan Woo Wee  6
    1 Department of Radiation Oncology, Seoul National University Hospital, Seoul, Korea.
    2 Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Korea.
    3 Department of Radiation Oncology, Seoul National University Bundang Hospital, Seongnam, Korea.
    4 Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
    5 Department of Otorhinolaryngology-Head and Neck Surgery, SMG-SNU Boramae Medical Center, Seoul, Korea.
    6 Department of Radiation Oncology, SMG-SNU Boramae Medical Center, Seoul, Korea.

  • 키워드
    General surgery; HPV; HPV-positive oropharyngeal cancer; Oropharynx; Radiotherapy.
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