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  • [Pediatr Blood Cancer.] Neurocognitive and psychological functioning of pediatric brain tumor patients undergoing proton beam therapy for three different tumor types

    국립암센터 / 윤상희, 하보람, 김주영*

  • 출처
    Pediatr Blood Cancer.
  • 등재일
    2022 Mar
  • 저널이슈번호
    69(3):e29430. doi: 10.1002/pbc.29430. Epub 2021 Nov 12.
  • 내용

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    Abstract
    Background: A high proportion of pediatric patients with brain tumors (BTs) are known to experience a decline in neurocognitive function after treatment. We prospectively examined neuropsychological functioning of patients with BTs of varying tumor types at different time points before, during, and after proton beam therapy.

    Materials and methods: A total of 98 patients with posterior fossa tumors (PFTs; n = 33), germ cell tumors (GCTs; n = 52), and other supratentorial tumors (STTs; n = 13) underwent baseline neuropsychological assessments and 57 patients underwent follow-up assessments.

    Results: All groups displayed significantly lower performance intelligence quotient (PIQ) and processing speed (PS) scores than the normative means at baseline. The PFT group exhibited significantly lower scores for full-scale IQ, PIQ, PS, attention, and executive function. The GCT group displayed full-scale IQ scores within the normal range, but a significantly high proportion had memory deficits. In the STT group, all functions except for the PIQ and PS were intact. Longitudinal evaluations demonstrated stable global IQ scores over time in all groups. In the PFT group, verbal comprehension, attention, and PS improved over time. However, in the GCT group, verbal IQ scores declined significantly and psychological problems worsened over time, which were correlated with poorer neurocognitive function at 3-5 years after treatment. In the STT group, no significant changes were observed.

    Conclusion: Because patients with BTs exhibit various types of neurocognitive deficit before radiotherapy, early cognitive treatment tailored to the tumor type maybe beneficial. Interventions for psychological problems and memory function may be necessary, especially for patients with GCT.

     

     

    Affiliations

    Sang Hee Youn  1 , Boram Ha  1 , Eun-Hee Lee  1 , Boram Park  2 , Song Ei Yang  1 , Eun-Seung Yu  3 , Joo-Young Kim  1
    1 Proton Therapy Center, National Cancer Center, Goyang, Republic of Korea.
    2 Biostatistics Collaboration Unit, National Cancer Center, Goyang, Republic of Korea.
    3 Mental Health Clinic, National Cancer Center, Goyang, Republic of Korea.

  • 키워드
    brain; neuropsychological function; pediatrics; proton therapy; tumor.
  • 편집위원

    소아 뇌종양 환자에서 양성자 치료 후 치료 부위 및 방사선치료 선량에 따라 neuropsychological function의 변화 및 회복 양상을 보여주는 흥미로운 연구입니다.

    2022-05-04 16:12:37

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