연세의대 / 김태형, 성진실*
Abstract
Purpose: For bone metastasis from hepatocellular carcinoma (HCC), radiotherapy (RT) has been used a palliative treatment with little impact on survival. Currently, ablative RT is popularly used, and a more than palliative effect is expected. Herein, we investigated the clinical efficacy of ablative RT in patients with bone metastasis from HCC.
Methods: In total, 530 patients with 887 lesions treated in 1992-2019 were reviewed. Oligometastasis was defined as the presence of < 5 lesions. Total doses were normalized to obtain biologically effective doses (BEDs). The cut-off threshold of the BED was determined via receiver operating characteristics curve analysis. The Kaplan-Meier method was used to calculate overall survival (OS); propensity score matching (PSM) was performed to balance the heterogeneity in cases while comparing BEDs of ≥ 60 and < 60 Gy.
Results: The most common site of metastasis was the spine (59%); 59 patients (11%) presented with oligometastasis, and 76.2% of patients showed objective pain palliation after RT. Median OS was 5.1 months for all patients; patients with oligometastasis showed longer OS than those without (9.8 vs. 4.7 months). A Cox proportional hazards model showed that performance status, Child-Pugh class, extraosseous metastasis, primary HCC status, α-fetoprotein level, and radiation dose (BED) were significant prognostic factors. Post PSM, BED was the only treatment-related prognostic factor that remained significant; the median OS durations were 8.1 and 4.4 months when the BEDs were ≥ 60 and < 60 Gy, respectively.
Conclusion: Ablative RT improved OS and pain palliation in patients with bone metastasis from HCC.
편집위원
간암의 뼈전이에서 방사선량에 따른 예후를 분석하였으며, BED 60 이상의 고선량방사선치료가 생존율 향상과 통증 완화에 이득이 있음을 보고함.
2021-10-19 14:43:54
편집위원2
HCC에서 동반되는 bone metastases는 bulky, soft tissue mass forming lesion인 경우가 많은데, 이때 고선량의 방사선치료를 적용할 수 있는 좋은 근거연구로 생각됩니다.
2021-10-19 14:46:37