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  • [In Vivo.] Undervaluation of Radiotherapy for Gross Desmoid Tumors: The Need for Absolute Volume Assessment

    울산의대 / 김연주, 송시열*

  • 출처
    In Vivo.
  • 등재일
    May-Jun 2021
  • 저널이슈번호
    35(3):1777-1784. doi: 10.21873/invivo.12437.
  • 내용

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    Abstract
    Background/aim: To compare absolute volume (AV) assessment according to Response Evaluation Criteria in Solid Tumors (RECIST) for the response evaluation of desmoid tumors (DTs) treated with radiotherapy.

    Patients and methods: Eighteen patients with DTs ≥3 cm in size were included.

    Results: The median follow-up duration was 78.0 months. Five patients achieved a complete response according to RECIST, seven reached a partial response (PR), and one eventually exhibited progression. The overall response rate was 61%, the median time to PR was 8.0 months. Six patients achieved stable disease, although three developed progressions. Of the six patients with a PR, the median change in maximum diameter was -46%, and the median change in maximum volume was -84%. Three patients could have been diagnosed with progression at least 6 months earlier if the AV increment was considered.

    Conclusion: An AV assessment is essential for an accurate response assessment of DTs and radiotherapy seems feasible as a first-line treatment for DTs.

     

     

    Affiliations

    Yeon Joo Kim  1 , Si Yeol Song  2 , Wanlim Kim  3 , Jongseok Lee  3 , Jin-Hee Ahn  4 , Jeong Eun Kim  4 , Hye Won Chung  5 , Seong-Yun Jeong  6 , Eun Kyung Choi  1
    1 Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    2 Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; siyeol.song@gmail.com.
    3 Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    4 Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    5 Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
    6 Asan Cancer Institute, Seoul, Republic of Korea.

  • 키워드
    Desmoid tumor; RECIST; absolute volume; radiotherapy; response assessment.
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