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  • [J Breast Cancer] Impact of Oncotype DX Recurrence Score on the Patterns of Locoregional Recurrence in Breast Cancer (Korean Radiation Oncology Group 19-06)

    서울의대 / 김규보, 정진홍, 신경환*

  • 출처
    J Breast Cancer
  • 등재일
    2020 May 21
  • 저널이슈번호
    23(3):314-319. doi: 10.4048/jbc.2020.23.e36. eCollection 2020 Jun.
  • 내용

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    Abstract
    The current study evaluated the impact of the Oncotype DX recurrence score (RS) on the patterns of locoregional recurrence (LRR) in node-negative, hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer. Totally, 339 patients from 4 institutions were enrolled and analyzed retrospectively. All patients underwent breast-conserving surgery followed by whole-breast irradiation; only 2 patients received regional nodal irradiation (RNI). The RS was < 11 in 55 patients, 11-25 in 241, and > 25 in 43. Sixty-two patients received adjuvant chemotherapy. All patients except 4 received hormonal therapy. During a 62-month median follow-up, local recurrence was observed in 1 patient; regional recurrence, 3; and distant metastasis, 7. All LRRs were observed among patients with a RS > 25, resulting in a 5-year LRR rate of 7.3% in this subgroup. Regional recurrences developed in patients did not receive RNI initially. Thus, RNI might be effective for patients with a high RS.

     


    Affiliations Collapse

    Kyubo Kim  1 , Jinhong Jung  2 , Kyung Hwan Shin  3 , Jin Ho Kim  3 , Ji Hyun Chang  3 , Su Ssan Kim  2 , Haeyoung Kim  4 , Won Park  4 , Yong Bae Kim  5 , Jee Suk Chang  5
    Affiliations
    1 Department of Radiation Oncology, Ewha Womans University College of Medicine, Seoul, Korea.
    2 Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    3 Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
    4 Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    5 Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

  • 키워드
    Breast neoplasm; Local neoplasm recurrence; Radiotherapy.
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