방사선방호 및 안전

  • Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study

    (IRSN/Klervi Leuraud*)

  • 출처
    Leuraud et al.
  • 등재일
    2015 July
  • 저널이슈번호
    2: e276–81
  • 내용

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    Summary

    Background There is much uncertainty about the risks of leukaemia and lymphoma after repeated or protracted lowdose

    radiation exposure typical of occupational, environmental, and diagnostic medical settings. We quantifi ed

    associations between protracted low-dose radiation exposures and leukaemia, lymphoma, and multiple myeloma

    mortality among radiation-monitored adults employed in France, the UK, and the USA.

     

    Methods We assembled a cohort of 308 297 radiation-monitored workers employed for at least 1 year by

    the Atomic Energy Commission, AREVA Nuclear Cycle, or the National Electricity Company in France,

    the Departments of Energy and Defence in the USA, and nuclear industry employers included in the

    National Registry for Radiation Workers in the UK. The cohort was followed up for a total of 8·22 million personyears.

    We ascertained deaths caused by leukaemia, lymphoma, and multiple myeloma. We used Poisson regression

    to quantify associations between estimated red bone marrow absorbed dose and leukaemia and lymphoma

    mortality.

     

    Findings Doses were accrued at very low rates (mean 1·1 mGy per year, SD 2·6). The excess relative risk of leukaemia

    mortality (excluding chronic lymphocytic leukaemia) was 2·96 per Gy (90% CI 1·17–5·21; lagged 2 years), most

    notably because of an association between radiation dose and mortality from chronic myeloid leukaemia (excess

    relative risk per Gy 10·45, 90% CI 4·48–19·65).

     

    Interpretation This study provides strong evidence of positive associations between protracted low-dose radiation

    exposure and leukaemia. 

     

    Author

    Klervi Leuraud, David B Richardson, Elisabeth Cardis, Robert D Daniels, Michael Gillies, Jacqueline A O’Hagan, Ghassan B Hamra, Richard Haylock,

    Dominique Laurier, Monika Moissonnier, Mary K Schubauer-Berigan, Isabelle Thierry-Chef, Ausrele Kesminiene 

     

    Institut de Radioprotection et de Sûreté Nucléaire, Fontenayaux-Roses, France (K Leuraud PhD, D Laurier PhD);

    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA (D B Richardson PhD); 

    Center for Research in Environmental Epidemiology, Barcelona, Spain (Prof E Cardis PhD); 

    Universitat Pompeu Fabra, Barcelona, Spain (Prof E Cardis); 

    CIBER Epidemiología y Salud Pública, Madrid, Spain (Prof E Cardis);

    National Institute for Occupational Safety and Health, Cincinnati, OH, USA (R D Daniels PhD, M K Schubauer-Berigan PhD);

    Public Health England Centre for Radiation, Chemical and Environmental Hazards, Chilton, UK (M Gillies MSc,J A O’Hagan HNC, R Haylock PhD);

    Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, PA, USA (G B Hamra PhD); 

    International Agency for Research on Cancer, Lyon, France (M Moissonnier BSc, I Thierry-Chef PhD, A Kesminiene MD)

     

    Correspondence to:

    Dr Klervi Leuraud, Institute for Radiological Protection and Nuclear Safety, Radiation Protection Division – Radiological Protection and Health, Radiobiology and Epidemiology Department, IRSN/PRP-HOM/SRBE, BP 17, Fontenay-aux-Roses Cedex, France

    klervi.leuraud@irsn.fr 

  • 연구소개
    INWORKS라는 미국,영국,프랑스 원전종사자들을 대상으로 한 연구로서 직업적 저선량 노출이 백혈병의 위험도를 증가시킨다는 내용입니다. 방사선의 직업적 노출 관련 최신 자료로서 중요한 의미를 내포하고 있다고 생각됩니다.
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