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  • [Nat Nanotechnol.] Nanoparticles as multimodal photon transducers of ionizing radiation.

    Weill Cornell Graduate School / Pratt EC*

  • 출처
    Nat Nanotechnol.
  • 등재일
    2018 May
  • 저널이슈번호
    13(5):418-426. doi: 10.1038/s41565-018-0086-2. Epub 2018 Mar 26.
  • 내용

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    Abstract
    In biomedical imaging, nanoparticles combined with radionuclides that generate Cerenkov luminescence are used in diagnostic imaging, photon-induced therapies and as activatable probes. In these applications, the nanoparticle is often viewed as a carrier inert to ionizing radiation from the radionuclide. However, certain phenomena such as enhanced nanoparticle luminescence and generation of reactive oxygen species cannot be completely explained by Cerenkov luminescence interactions with nanoparticles. Herein, we report methods to examine the mechanisms of nanoparticle excitation by radionuclides, including interactions with Cerenkov luminescence, β particles and γ radiation. We demonstrate that β-scintillation contributes appreciably to excitation and reactivity in certain nanoparticle systems, and that excitation by radionuclides of nanoparticles composed of large atomic number atoms generates X-rays, enabling multiplexed imaging through single photon emission computed tomography. These findings demonstrate practical optical imaging and therapy using radionuclides with emission energies below the Cerenkov threshold, thereby expanding the list of applicable radionuclides.

     


    Author information

    Pratt EC1, Shaffer TM2,3,4,5,6, Zhang Q3,4,5, Drain CM4,5, Grimm J7,8,9,10.
    1
    Department of Pharmacology, Weill Cornell Graduate School, New York, NY, USA.
    2
    Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    3
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    4
    Department of Chemistry, Hunter College, City University of New York, New York, NY, USA.
    5
    Department of Chemistry, The Graduate Center of the City University of New York, New York, NY, USA.
    6
    Department of Radiology, Stanford University, Stanford, CA, USA.
    7
    Department of Pharmacology, Weill Cornell Graduate School, New York, NY, USA. grimmj@mskcc.org.
    8
    Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. grimmj@mskcc.org.
    9
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. grimmj@mskcc.org.
    10
    Department of Radiology, Weill Cornell Medical College, New York, NY, USA. grimmj@mskcc.org.

  • 편집위원

    Radiolabeling된 nanoparticle을 포함, 다른 여타 물질의 이미징을 할 때 제한점 중 하나가 multiplexing이었는데, radioactive material과 상호작용으로 nanoparticle에서 특성화된 X-ray를 방출하는 것을 관찰, 이를 통해 multiplexing의 가능성을 보여준 논문입니다.

    2018-06-21 11:18:39

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