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  • [Biomaterials.] Role of nuclear mechanosensitivity in determining cellular responses to forces and biomaterials.

    단국대/ 이정환, 김해원*

  • 출처
    Biomaterials.
  • 등재일
    2019 Mar
  • 저널이슈번호
    197:60-71. doi: 10.1016/j.biomaterials.2019.01.010. Epub 2019 Jan 8.
  • 내용

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    Abstract
    Tissue engineers use biomaterials or apply forces to alter cell behaviors and cure damaged/diseased tissues. The external physical cues perceived by cells are transduced intracellularly along the mechanosensitive machineries, including subcellular adhesion molecules and cytoskeletons. The signals are further channeled to a nucleus through the physical links of nucleoskeleton and cytoskeleton or the biochemical translocation of transcription factors. Thus, the external cues are thought to affect directly or indirectly the nucleus and the genetic transcriptional process, ultimately determining cell fate. Here we communicate the importance of such mechanotransductory processes in cell and tissue engineering where external forces- or biomaterials-related physical cues essentially regulate cellular behaviors, with an emphasis on the mechanosensing and signaling along the road to a nucleus.

     


    Author information

    Lee JH1, Kim DH2, Lee HH1, Kim HW3.
    1
    Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea; Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Republic of Korea; UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, Republic of Korea.
    2
    KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 20841, South Korea.
    3
    Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea; Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan 31116, Republic of Korea; Department of Nanobiomedical Science & BK21 PLUS Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea; UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, Republic of Korea. Electronic address: kimhw@dku.edu

  • 키워드
    Adhesion molecules; Cell engineering; External physical cues; Mechanotransduction; Nucleus
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