바로가기  >

Abstract
We provide immense insulin absorption from the gastrointestinal tract, combining apical sodium-dependent bile acid transporter-mediated intestinal uptake and the lymphatic transport pathway. This strategy has proven to employ chondroitin sulfate- g-taurocholic acid coated, insulin-loaded partially uncapped liposome (IPUL-CST) for type 1 diabetes mellitus (T1DM) treatment. The loading efficiency of insulin in IPUL-CST increased significantly from 33% to 75% via the partially uncapped liposome preparation method. Moreover, the IPUL-CST revealed an improved insulin protection efficacy in GIT simulated pH and digestive enzyme conditions. The high dose of IPUL-CST in the small intestine was detected 4 h post-oral administration using ex vivo optical imaging and fluorescence intensity. The IPUL-CST exhibited significantly enhanced intestinal absorption (oral bioavailability, 34%; Tmax, 9 h) and reduced blood glucose levels for 16 h in T1DM. The results demonstrated that the new investigated IPUL-CST is a promising carrier for oral insulin delivery.

Author information

Kim KS1, Kwag DS2, Hwang HS1, Lee ES2, Bae YH1.
1
Department of Pharmaceutics and Pharmaceutical Chemistry , University of Utah , Salt Lake City , Utah 84112 , United States.
2
Department of Biotechnology , The Catholic University of Korea , 43-1 Yeokgok 2-dong, Wonmi-gu , Bucheon , Gyeonggi-do 420-743 , Republic of Korea.