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  • [ACS Nano.] Morphology-Controlled Synthesis of Rhodium Nanoparticles for Cancer Phototherapy.

    기초과학연구원, 성균관대 / 강승훈, 민달희*,장홍제*

  • 출처
    ACS Nano.
  • 등재일
    2018 Jul 24
  • 저널이슈번호
    12(7):6997-7008. doi: 10.1021/acsnano.8b02698. Epub 2018 Jun 22.
  • 내용

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    Abstract
    Rhodium nanoparticles are promising transition metal nanocatalysts for electrochemical and synthetic organic chemistry applications. However, notwithstanding their potential, to date, Rh nanoparticles have not been utilized for biological applications; there has been no cytotoxicity study of Rh reported in the literature. In this regard, the absence of a facile and controllable synthetic strategy of Rh nanostructures with various sizes and morphologies might be responsible for the lack of progress in this field. Herein, we have developed a synthetic strategy for Rh nanostructures with controllable morphology through an inverse-directional galvanic replacement reaction. Three types of Rh-based nanostructures-nanoshells, nanoframes, and porous nanoplates-were successfully synthesized. A plausible synthetic mechanism based on thermodynamic considerations has also been proposed. The cytotoxicity, surface functionalization, and photothermal therapeutic effect of manufactured Rh nanostructures were systematically investigated to reveal their potential for in vitro and in vivo biological applications. Considering the comparable behavior of porous Rh nanoplates to that of gold nanostructures that are widely used in nanomedicine, the present study introduces Rh-based nanostructures into the field of biological research.

     


    Author information

    Kang S1, Shin W2, Choi MH1, Ahn M1,3, Kim YK4, Kim S5, Min DH1,3, Jang H2.
    1
    Center for RNA Research , Institute for Basic Science (IBS) , Seoul 08826 , Republic of Korea.
    2
    Department of Chemistry , Kwangwoon University , 20, Gwangwoon-ro , Nowon-gu, Seoul 01897 , Republic of Korea.
    3
    Institute of Biotherapeutics Convergence Technology , Lemonex Inc. , Seoul 08826 , Republic of Korea.
    4
    Carbon Composite Materials Research Center, Institute of Advanced Composite Materials , Korea Institute of Science and Technology , San 101, Eunha-ri, Bongdong-eup, Wanju-gun , Jeollabuk-do 565-905 , Republic of Korea.
    5
    Division of Chemistry & Molecular Engineering , and ^Department of Chemistry , Seoul National University , Seoul 08826 , Republic of Korea.

  • 키워드
    cancer therapy; galvanic replacement; morphology control; photothermal conversion; rhodium
  • 편집위원

    로듐(Rh)나노입자는 전기화학촉매와 유기합성화학 응용에 광범위하게 사용되고 있는 전이금속 원소 기반 나노물질이지만, 생물학적 응용 분야에 있어서 적용되지 못하고 있다. 이 논문은 나노쉘, 나노프레임, 다공성 나노플레이트 구조의 로듐 나노입자를 이용하여 세포 독성, 표면 개질 및 광열 치료 효과를 세포 및 동물 모델에서 확인한 것으로, 로듐을 이용한 다공성 로듐 나노플레이트의 생물학 연구 분야를 여는데 기여할 수 있을 것이다.

    2018-08-28 11:51:29

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