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  • [Bioconjug Chem.] Biocompatible and Biodegradable Fe3+-Melanoidin Chelate as a Potentially Safe Contrast Agent for Liver MRI.

    성균관의대 / 이민영, 이정희*

  • 출처
    Bioconjug Chem.
  • 등재일
    2018 Jun 28. doi: 10.1021/acs.bioconjchem.8b00331.
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    Abstract
    Currently, most MRI probes available for clinical use contain gadolinium, which is a high-risk paramagnetic metal that can cause severe side effects (e.g., nephrogenic systemic fibrosis). To limit such side effects and improve diagnostic efficacy, we developed a novel biocompatible MRI contrast agent using glucose, glycine, and paramagnetic iron ion. Glucose and glycine were polymerized into melanoidin by the nonenzymatic Maillard reaction, and Fe3+ was chelated stably with the melanoidin during polymerization. The Fe3+-melanoidin chelate had biocompatibility, biodegradability, and unique contrast effects on both T1- and T2-weighted MRI, depending on the pH and oxidative environments. The administration of the Fe3+-melanoidin chelate to a mouse model of liver cancer showed highly enhanced liver-to-tumor contrasts on both T1- and T2-weighted MRI.

     


    Author information

    Lee MY1,2, Choi D1,2,3, Jang MS2,3, Lee JH2,3.
    1
    Smart Healthcare Medical Device Research Center , Samsung Medical Center , 81, Irwon-ro , Gangnam-gu, Seoul 06351 , Republic of Korea.
    2
    Samsung Advanced Institute for Health Sciences & Technology (SAIHST) , Sungkyunkwan University , 81 Irwon-ro , Gangnam-gu, Seoul 06351 , Republic of Korea.
    3
    Department of Radiology , Samsung Medical Center, Sungkyunkwan University School of Medicine , 81, Irwon-ro , Gangnam-gu, Seoul 06351 , Republic of Korea.

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