글로벌 연구동향
방사선생물학
- 2021년 07월호
[Nanoscale.] Ultrasmall Gd@Cdots as a radiosensitizing agent for non-small cell lung cancerUniversity of Georgia,University of NorthCarolina, Augusta University/이채빈,WenJiang*,ZiboLi*,JinXie*
- 출처
- Nanoscale.
- 등재일
- 2021 May 28
- 저널이슈번호
- 13(20):9252-9263. doi: 10.1039/d0nr08166c. Epub 2021 May 13.
- 내용
Abstract
High-Z nanoparticles (HZNPs) afford high cross-section for high energy radiation and have attracted wide attention as a novel type of radiosensitizer. However, conventional HZNPs are often associated with issues such as heavy metal toxicity, suboptimal pharmacokinetics, and low cellular uptake. Herein, we explore gadolinium-intercalated carbon dots (Gd@Cdots) as a dose-modifying agent for radiotherapy. Gd@Cdots are synthesized through a hydrothermal reaction with an ultrasmall size (∼3 nm) and a high Gd content. Gd@Cdots can significantly increase hydroxyl radical production under X-ray irradiation; this is attributed to not only the photoelectric effects of Gd, but also the surface catalytic effects of carbon. Because carbon is biologically and chemically inert, Gd@Cdots show low Gd leakage and minimal toxicity. In vitro studies confirm that Gd@Cdots can efficiently enhance radiation-induced cellular damage, causing elevated double strand breaks, lipid peroxidation, and mitochondrial depolarization. When tested in mice bearing non-small cell lung cancer H1299 tumors, intravenously injected Gd@Cdots plus radiation leads to improved tumor suppression and animal survival relative to radiation alone while causing no detectable toxicity. Our studies suggest a great potential of Gd@Cdots as a safe and efficient radiosensitizer.Affiliation
Chaebin Lee 1 , Xiangji Liu, Weizhong Zhang, Michael A Duncan, Fangchao Jiang, Christine Kim, Xuefeng Yan, Yong Teng, Hui Wang, Wen Jiang, Zibo Li, Jin Xie
1 Department of Chemistry, University of Georgia, 140 Cedar Street, Athens, GA 30602, USA. jinxie@uga.edu wen.jiang@uga.edu.
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